RESTRICTION OF IN-VITRO T CELL-MEDIATED CYTOTOXICITY IN LYMPHOCYTIC CHORIOMENINGITIS WITHIN A SYNGENEIC OR SEMIALLOGENEIC SYSTEM
RESTRICTION OF IN-VITRO T CELL-MEDIATED CYTOTOXICITY IN LYMPHOCYTIC CHORIOMENINGITIS WITHIN A SYNGENEIC OR SEMIALLOGENEIC SYSTEM
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DOI：
10.1038/248701a0
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发表时间：
1974-01-01
期刊：
影响因子：
64.8
通讯作者：
DOHERTY, PC
中科院分区：
文献类型：
--
作者：
ZINKERNA.RM;DOHERTY, PC
最近的实验表明，胸腺源性淋巴细胞（T细胞）和抗体形成细胞前体（B细胞）之间的合作受到H-2基因复合物的限制。只有当T细胞和B细胞至少共享一组H-2抗原特异性时，辅助性活性才能在体内起作用。有证据表明，细胞毒性T细胞与感染4 - 5淋巴细胞性脉络丛脑膜炎（LCM）病毒的其他体细胞的相互作用同样受到限制。
RECENT experiments1–3indicate that cooperation between thymus derived lymphocytes (T cells) and antibody-forming cell precursors (B cells) is restricted by the H-2 gene complex. Helper activityin vivooperates only when T cells and B cells share at least one set of H-2 antigenic specificities. Evidence is presented here that the interaction of cytotoxic T cells with other somatic cells budding4–5lymphocytic choriomeningitis (LCM) virus is similarly restricted.