A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy
A phase I, randomized study of combined IL-2 and therapeutic immunisation with antiretroviral therapy
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通讯作者：
G. Hardy;N. Imami;M. Nelson;Ann K Sullivan;Ron Moss;Marlén MI Aasa-Chapman;Brian Gazzard;Frances M. Gotch
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作者：
G. Hardy;N. Imami;M. Nelson;Ann K Sullivan;Ron Moss;Marlén MI Aasa-Chapman;Brian Gazzard;Frances M. Gotch
背景：完全功能的hiv -1特异性CD8和CD4效应t细胞反应对于遏制病毒活性和疾病进展至关重要。这些反应在hiv -1感染的进行性疾病患者中缺乏。我们试图在晚期慢性HIV-1感染患者中增强完全功能的HIV-1特异性CD8和CD4效应t细胞反应。
Background: Fully functional HIV-1-specific CD8 and CD4 effector T-cell responses are vital to the containment of viral activity and disease progression. These responses are lacking in HIV-1-infected patients with progressive disease. We attempted to augment fully functional HIV-1-specific CD8 and CD4 effector T-cell responses in patients with advanced chronic HIV-1 infection.