Association between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects.
Association between insulin resistance and cognition in patients with depressive disorders: exploratory analyses into age-specific effects.
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DOI：
10.1016/j.jpsychires.2014.10.001
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发表时间：
2015
影响因子：
4.8
通讯作者：
T. Wroolie;H. Kenna;Manpreet K. Singh;N. Rasgon
中科院分区：
文献类型：
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作者：
T. Wroolie;H. Kenna;Manpreet K. Singh;N. Rasgon
目前的初步横断面研究试图检验胰岛素抵抗(IR)和体重指数(BMI)对有抑郁症病史的成年患者认知能力的影响，目前这些患者并不在急性重度抑郁发作(MDD)中。作为一项探索性的特别调查，特别考虑了45岁的成年人和45岁的≥。研究对象包括年龄在19-71岁(N=39)的有非精神病史、非忧郁性MDD病史的男性和女性。所有受试者都接受了胰岛素抑制试验，以确定稳态血糖(SSPG)，一系列神经心理测试，并测量BMI。通过多元线性回归来确定直接测量和间接测量对整个样本和分成两个年龄组(45岁和≥45岁)的认知是否有不同的影响。初步结果表明，在整个样本中，直接测量和间接测量在任何认知变量上都不与较差的表现相关，而较高的体重指数与较差的优势手精细运动技能有关。在年龄段内，SSPG和BMI对认知的影响存在差异。在45岁组中，较高的SSPG与较差的认知灵活性有关，而在≥45岁组中，较高的体重指数与较差的全球智力估计有关。IR对患有抑郁症的年轻人的潜在负面影响引发了人们对未确诊的患有IR和抑郁症的年轻人的认知和阿尔茨海默病风险的长期影响的担忧。在年轻成人人群中间接测量IR可能看不到这些负面后果。有抑郁症病史的老年人超重和肥胖似乎对认知有进一步的负面影响，类似于糖尿病患者的缺陷。临床试验。政府识别临床试验NCT01106313
The current preliminary cross sectional study sought to examine the effects of insulin resistance (IR) and body mass index (BMI) on cognitive performance in adult patients with a history depression, currently not in an acute Major Depressive Episode (MDD). As an exploratory post hoc investigation, special consideration was given to adults <45 years and ≥45 years old.Subjects included men and women ages 19-71 (N= 39) with a history of a non-psychotic, non-melancholic MDD. All subjects underwent an insulin suppression test to determine Steady-State Plasma Glucose (SSPG), a battery of neuropsychological tests, and measurement of BMI. Multiple linear regressions were conducted to determine whether there were differential effects of direct (SSPG) and indirect (BMI) measures on cognition in the whole sample and within dichotomized age groups (<45 and ≥45 years).Preliminary results showed that in the sample as a whole, SSPG was not associated with worse performance on any cognitive variables, while higher BMI was associated with worse dominant hand fine motor skills. Within age groups, differential effects on cognition were found in relation to SSPG and BMI. Higher SSPG was associated with worse cognitive flexibility in the group <45 years, whereas higher BMI was associated with worse estimate of global intelligence in the group ≥45 years.The potential negative impact of IR in younger adults with depression raises concerns regarding the long-term impact on cognition and risk for Alzheimer's disease in undiagnosed younger adults with IR and depression. These negative consequences may not be seen with indirect measures of IR in younger adult populations. Overweight and obesity in older adults with a history of depression appear to have further negative impacts on cognition similar to deficits seen in patients with diabetes.ClinicalTrials.gov IdentifierClinical Trial NCT01106313