Endoplasmic reticulum stress response and regulated intramembrane proteolysis in plants
Endoplasmic reticulum stress response and regulated intramembrane proteolysis in plants
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DOI：
10.5511/plantbiotechnology.25.271
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发表时间：
2008-06
影响因子：
1.6
通讯作者：
H. Tajima;Yuji Iwata;N. Koizumi
中科院分区：
文献类型：
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作者：
H. Tajima;Yuji Iwata;N. Koizumi
在内质网（ER）应激反应中，ER中的蛋白质折叠被扰乱，导致编码促进蛋白质正确折叠的蛋白质的基因的诱导。内质网应激反应的信号通路的独特机制已在酵母和动物中进行了研究。在动物中，已经报道了几种具有受调节的膜内蛋白水解（RIP）控制的跨膜结构域的bZIP型转录因子参与信号传导途径。最近，AtbZIP60，这是一个跨膜结构域的bZIP类型的转录因子，被确定为参与在拟南芥的内质网应激反应。其他几个转录因子，似乎是由RIP调节也已在拟南芥中报道。对AtbZIP60调控机制的分析将有助于理解植物内质网应激反应和RIP。
In the endoplasmic reticulum (ER) stress response, protein folding in the ER is disturbed, resulting in the induction of genes encoding proteins that facilitate correct folding of proteins. Unique mechanism of signaling pathway in the ER stress response has been studied in yeast and animals. In animals, several bZIP type transcription factors with a transmembrane domain controlled by regulated intramembrane proteolysis (RIP) have been reported to be involved in the signaling pathway. Very recently, AtbZIP60, which is a bZIP type transctiption factor with a transmembrane domain, was identified to be involved in the ER stress response in Arabidopsis. Several other transctiption factors that seem to be regulated by RIP have been also reported in Arabidopsis. Analysis of the regulation mechanism of AtbZIP60 will contribute to understanding of the ER stress response and RIP in plants.