MICROGLANDULAR ADENOSIS OF THE BREAST - A CLINICOPATHOLOGIC STUDY OF 11 CASES WITH ULTRASTRUCTURAL OBSERVATIONS
MICROGLANDULAR ADENOSIS OF THE BREAST - A CLINICOPATHOLOGIC STUDY OF 11 CASES WITH ULTRASTRUCTURAL OBSERVATIONS
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DOI：
10.1097/00000478-198307080-00002
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发表时间：
1983-01-01
影响因子：
5.6
通讯作者：
NORRIS, HJ
中科院分区：
文献类型：
--
作者：
TAVASSOLI, FA;NORRIS, HJ
本文报告11例乳腺微腺腺病的临床和病理特点。微腺腺病是一种罕见的良性病变，很容易与癌混淆。其特征是在致密均匀的间质中有圆形腺体的集中增生，并有开放的管腔，与相邻的未受累乳房清楚地区分开来。腺体内衬单层细胞，细胞质明显空泡化或颗粒状。超微结构上，单层上皮细胞缺乏胞质突起，被厚的多层基底膜包围。光镜和EM功能，有助于区分微腺腺病分化良好（管状）癌和硬化性腺病，它是容易混淆的实体，进行了讨论。
The clinical and pathologic features of 11 examples of microglandular adenosis of the breast are presented. Microglandular adenosis is a rare, benign lesion that is easily confused with carcinoma. It is characterized by a concentrated proliferation of round glands with open lumens in a densely homogeneous stroma that clearly delineates microglandular adenosis from the adjacent uninvolved breast. The glands are lined by a single layer of cells with distinctly vacuolated or granular cytoplasm. Ultrastructurally, the single layer of epithelial cells lacks cytoplasmic protrusions and is surrounded by a thick multilayered basement membrane. Light microscopic and EM features that help distinguish microglandular adenosis from well-differentiated (tubular) carcinoma and sclerosing adenosis, entities with which it is easily confused, are discussed.