POSTNATAL SERUM INSULIN-LIKE GROWTH FACTOR I AND RETINOPATHY OF PREMATURITY.
POSTNATAL SERUM INSULIN-LIKE GROWTH FACTOR I AND RETINOPATHY OF PREMATURITY.
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DOI：
10.1097/iae.0000000000001247
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
Binenbaum G
中科院分区：
文献类型：
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作者：
Jensen AK;Ying GS;Huang J;Quinn GE;Binenbaum G
低血清胰岛素样生长因子1（IGF-1）与严重早产儿视网膜病变（ROP）的发生有关，但尚未有美国研究报告。我们试图确定出生后血清IGF-1水平和严重ROP之间的关系，在美国的种族多样化的队列。费城3家医院74例出生体重（BW）<1251 g且已知ROP结局的婴儿的前瞻性队列研究。每周一次的出生后滤纸血斑IGF-1测定），直到42周的月经后年龄（PMA）。该队列包括20名白人、45名黑人、2名亚洲人和9名其他婴儿;中位胎龄（GA）27.6周（范围23-33）;中位BW 975 g（范围490-1250）。在PMA第28 - 33周期间，无ROP（n=46）的平均IGF-1为20.0 ng/mL（SE 0.52），第1或2期（n=23）为18.0（0.49），第3期（n=5，2例激光治疗）为17.0（0.70）（p=0.003）。BW和GA的调整显示出类似的结果。在一个种族多样的美国样本中，发现出生后低血清IGF和ROP之间的关联的存在和时间与欧洲队列一致。这种关联为基于生长的预测模型提供了病理生理学基础，这可以提高ROP筛查的效率。
Low serum insulin-like growth factor 1 (IGF-1) has been associated with development of severe retinopathy of prematurity (ROP), but no U.S. studies have been reported. We sought to determine the relationship between postnatal serum IGF-1 levels and severe ROP in a racially diverse U.S. cohort. Prospective cohort study of 74 infants with birth weight (BW) <1251g and a known ROP outcome at 3 Philadelphia hospitals. Weekly postnatal filter-paper bloodspot IGF-1 assays) were measured through 42 weeks postmenstrual age (PMA). The cohort included 20 Caucasian, 45 black, 2 Asian, and 9 other infants; median gestational age (GA) 27.6 weeks (range 23-33); median BW 975g (range 490-1250). During PMA weeks 28 to 33, mean IGF-1 was 20.0 ng/mL(SE 0.52) for no ROP (n=46), 18.0(0.49) for stage 1 or 2 (n=23), and 17.0(0.70) for stage 3 (n=5, 2 lasered) (p=0.003). Adjustment for BW and GA showed similar results. Presence and timing of an association between low postnatal serum IGF and ROP in a racially diverse U.S. sample were found to be consistent with European cohorts. This association provides the pathophysiological basis for growth-based predictive models, which could improve efficiency of ROP screening.