Perivascular cells and tissue engineering: Current applications and untapped potential.
Perivascular cells and tissue engineering: Current applications and untapped potential.
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DOI：
10.1016/j.pharmthera.2016.11.002
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发表时间：
2017-03
影响因子：
13.5
通讯作者：
Campagnolo P
中科院分区：
文献类型：
--
作者：
Avolio E;Alvino VV;Ghorbel MT;Campagnolo P
组织工程学的发展为衰竭器官的替代和损伤组织的修复提供了新的前景。血管周围细胞，包括血管平滑肌细胞、周细胞和其他存在于血管周围的组织特异性群体，已经从许多器官中分离出来，并且已知参与原位修复过程和血管生成。它们的潜力已被用于多种病理的细胞治疗;然而，在这次审查中，我们将讨论血管周围细胞在医疗保健组织工程解决方案开发中的潜力。我们将研究它们在血管移植物、心脏补片和骨替代物以及其他组织工程应用中的应用，我们将重点关注它们在工程结构血管化中的广泛应用。此外，我们还将讨论人类周细胞在开发高效、血管化和非免疫原性工程构建体方面的新兴潜力。
The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare. We will examine their application in the engineering of vascular grafts, cardiac patches and bone substitutes as well as other tissue engineering applications and we will focus on their extensive use in the vascularization of engineered constructs. Additionally, we will discuss the emerging potential of human pericytes for the development of efficient, vascularized and non-immunogenic engineered constructs.