Ethnic Differences in Pediatric Systemic Lupus Erythematosus
Ethnic Differences in Pediatric Systemic Lupus Erythematosus
复制标题
DOI：
10.3899/jrheum.081141
复制
发表时间：
2009-11-01
影响因子：
3.9
通讯作者：
Silverman, Earl D.
中科院分区：
文献类型：
--
作者：
Hiraki, Linda T.;Benseler, Susanne M.;Silverman, Earl D.
Objective.成人系统性红斑狼疮（SLE）的患病率和严重程度在不同种族之间有明显差异。在儿童SLE（pSLE）中，种族的影响并没有得到很好的描述。我们比较了不同种族pSLE的患病率和主要器官受累程度、疾病活动性和损害。在多伦多病童医院随访的265例pSLE患者的初始队列的种族人口学特征被确定，并与大都会多伦多的高危人群进行比较。患者根据自己指定的种族来源分为种族亚组。疾病特征包括主要器官受累、疾病活动性和损害程度进行了纵向测定，并在种族组间进行了比较。259/265例pSLE患者（99.6%）的种族数据可用;与大都会多伦多高危人群（40%）相比，大多数为非高加索人（60%）（p < 0.0001）。非白人患者在诊断时比白人患者年轻，黑人患者在诊断时最年轻（12.6 vs 14.6岁p = 0.007）。肾脏疾病在非白种人pSLE患者中明显比在白种人pSLE患者中更常见（62% vs 45%; p = 0.01）。与亚洲患者相比，黑人患者中枢神经系统疾病的患病率有增加的趋势（p = 0.108）。在性别比例、SLE疾病活动指数或损伤评分方面，种族组之间没有差异。非高加索人种与pSLE患病率增加相关。非白种人pSLE患者明显更年轻，更容易患肾炎。然而，疾病活动和损害与主要器官疾病密切相关，与患者的种族无关。（2009年10月15日首次发布; J Rheumol 2009：36：2539-46; doi：10.3899/Jrheum.081141）
Objective. Prevalence and severity of systemic lupus erythematosus (SLE) in adults is suggested to be distinctly different between ethnic groups. The impact of ethnicity is not as well delineated in pediatric SLE (pSLE). We compared prevalence and extent of major organ involvement, disease activity, and damage in pSLE between different ethnic groups.Methods. Ethnic demographic profiles of an inception cohort of 265 patients with pSLE followed at Sick Kids Hospital in Toronto were determined and compared to the Metropolitan Toronto at-risk Population. Patients were categorized into ethnic subsets based oil self-designated ethnic origins. Disease characteristics including major organ involvement, disease activity, and damage measures were longitudinally determined and compared among ethnic groups.Results. Ethnicity data were available oil 259/265 pSLE patients (99.6%); the majority were non-Caucasian (60%) compared to the Metropolitan Toronto at-risk population (40%) (p < 0.0001). Non-Caucasian patients were younger at diagnosis than Caucasian patients, Black patients being the youngest at diagnosis (12.6 vs 14.6 yrs p = 0.007). Renal disease was significantly more common in non-Caucasian than in Caucasian pSLE patients (62% vs 45%; p = 0.01). There was a trend toward increased prevalence of central nervous system disease in Black patients compared to Asian patients (p = 0.108). There was no difference in gender ratio, SLE Disease Activity Index, or damage scores between ethnic groups.Conclusion. Non-Caucasian ethnicity is associated with increased pSLE disease prevalence. Non-Caucasian pSLE patients were significantly younger and more likely to have nephritis. However, disease activity and damage were strongly associated with major organ disease independent of the patient's ethnicity. (First Release Oct 15 2009; J Rheumatol 2009:36:2539-46; doi: 10.3899/Jrheum.081141)