Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients.
Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients.
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DOI：
10.1038/s41598-018-33123-5
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发表时间：
2018-10-19
影响因子：
4.6
通讯作者：
Lu DC
中科院分区：
文献类型：
--
作者：
Freyvert Y;Yong NA;Morikawa E;Zdunowski S;Sarino ME;Gerasimenko Y;Edgerton VR;Lu DC
对6例C5以上、伤后1年以上的运动完全性损伤(AISB)患者，观察了颈椎电刺激与单胺类激动剂丁螺环酮联合应用对上肢运动功能的影响。通过受控手部收缩、握力产生、灵巧性测量和有效的临床评估组合来评估自主性上肢功能。重复测量方差分析用于评估功能指标、肌电幅度和平均握力的变化。总体而言，经皮电刺激和丁螺环酮的平均手力增加了300%以上，同时在上肢运动评分和动作研究手臂测试中观察到了相应的临床显著改善。在研究干预停止后，一些功能改善持续了很长一段时间。我们证明，有了这些新的干预措施，颈椎神经回路可以被神经调节，以改善四肢瘫痪受试者手功能的意志控制。这些发现对上肢瘫痪患者的潜在影响可能在功能上、心理上和经济上都是戏剧性的。
The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated through measures of controlled hand contraction, handgrip force production, dexterity measures, and validated clinical assessment batteries. Repeated measure analysis of variance was used to evaluate functional metrics, EMG amplitude, and changes in mean grip strength. In aggregate, mean hand strength increased by greater than 300% with transcutaneous electrical stimulation and buspirone while a corresponding clinically significant improvement was observed in upper extremity motor scores and the action research arm test. Some functional improvements persisted for an extended period after the study interventions were discontinued. We demonstrate that, with these novel interventions, cervical spinal circuitry can be neuromodulated to improve volitional control of hand function in tetraplegic subjects. The potential impact of these findings on individuals with upper limb paralysis could be dramatic functionally, psychologically, and economically.
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通过脊髓回路的多维单胺能调节来控制特定的运动行为。
DOI：
10.1523/jneurosci.5796-10.2011
发表时间：
2011-06-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Musienko P;van den Brand R;Märzendorfer O;Roy RR;Gerasimenko Y;Edgerton VR;Courtine G
通讯作者：
Courtine G
影响因子：
4.2
作者：
Gad, Parag;Lee, Sujin;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie
影响因子：
4.2
作者：
Leech, Kristan A.;Kinnaird, Catherine R.;Hornby, T. George
通讯作者：
Hornby, T. George
影响因子：
2.5
作者：
Gerasimenko, Yury P.;Ichiyama, Ronaldo M.;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie
影响因子：
2.5
作者：
Gerasimenko, Yury;Gorodnichev, Ruslan;Edgerton, V. Reggie
通讯作者：
Edgerton, V. Reggie