PHOSPHATIDYLINOSITOL MEMBRANE ANCHORS AND T-CELL ACTIVATION
PHOSPHATIDYLINOSITOL MEMBRANE ANCHORS AND T-CELL ACTIVATION
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DOI：
10.1016/0167-5699(91)90110-f
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发表时间：
1991-01-01
期刊：
影响因子：
--
通讯作者：
ROBINSON, PJ
中科院分区：
文献类型：
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作者：
ROBINSON, PJ
许多淋巴细胞蛋白通过糖磷脂酰肌醇锚定结构域附着在细胞膜上。针对其中几种蛋白质的抗体是T细胞的强大有丝分裂原。在这篇文章中，Peter Robinson回顾了这些膜锚参与细胞信号事件的最新证据，并讨论了它们在向淋巴样细胞提供非抗原依赖的共刺激信号方面的可能意义。
A number of lymphocyte proteins are attached to the cell membrane via glycophosphatidylinositol-anchoring domains. Antibodies specific for several of these proteins are potent mitogens for T cells. In this article, Peter Robinson reviews recent evidence for the involvement of these membrane anchors in cell signalling events and discusses their possible significance in providing antigen-independent costimulatory signals to lymphoid cells.