Impacts of structural photomodification on the toxicity of environmental contaminants: Anthracene photooxidation products
Impacts of structural photomodification on the toxicity of environmental contaminants: Anthracene photooxidation products
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DOI：
10.1006/eesa.1999.1764
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发表时间：
1999-06-01
影响因子：
6.8
通讯作者：
Greenberg, BM
中科院分区：
文献类型：
--
作者：
Mallakin, A;McConkey, BJ;Greenberg, BM
已知多环芳烃（PHA）的毒性通过光经由光敏化反应（活性氧的产生）和化学品的光改性（例如，氧化）为毒性更大的化合物。特别是蒽（ANT）的毒性已被发现在光改性后急剧增加。本研究的目的是确定ANT的光氧化产物，并评估选定的光产物的毒性。蒽光氧化的高效液相色谱（HPLC）分析揭示了一系列复杂的氧化产物，其中普遍的是蒽醌（ATQ）和羟基蒽醌（hATQs）。其中11种化合物仅使用浮萍Lemna gibba L的生长抑制作用进行毒性测试。G-3除一种化合物外，所有测试化合物均被发现有毒，当光源中存在紫外线辐射时，毒性通常会增强。在毒性测试之前，化学品也在SSR下辐照。在大约一半的情况下，ATQ化合物只是迅速光氧化，所得的光产物比母体化合物毒性更大。有趣的是，2-羟基蒽醌，这是不受光氧化，是最有毒的化合物测试。作为一种光稳定化合物，它存在持续环境危害的风险。(C)北京：科学出版社.
The toxicity of polycyclic aromatic hydrocarbons (PHAs) is known to be enhanced by light via photosensitization reactions (production of active oxygen) and photomodification of the chemicals (e.g., oxidation) to more toxic compounds. Anthracene (ANT) toxicity in particular has been found to increase dramatically following photomodification. The objective of this study was to identify the photooxidation products of ANT and assess the toxicity of selected photoproducts. High performance liquid chromatography (HPLC) analysis of anthracene photooxidation revealed a complex array of oxidation products; prevalent among these were anthraquinone (ATQ) and hydroxy-anthraquinones (hATQs). Eleven of these compounds mere tested for toxicity using growth inhibition of the duckweed Lemna gibba L. G-3. All but one of the compounds tested were found to be toxic, and when UV radiation was present in the light source toxicity was generally enhanced. The chemicals mere also irradiated under SSR prior to toxicity testing. In about half the cases, the ATQ compounds mere rapidly photooxidized and the resultant photoproducts were more toxic than the parent compounds. Interestingly, 2-hydroxyanthraquinone, which was not subject to photooxidation, was the most toxic of the compounds tested. As a light stable compound it presents the risk of a persistent environmental hazard. (C) 1999 Academic Press.