Cellular mechanisms underlying activity patterns in the monkey thalamus during visual behavior.
Cellular mechanisms underlying activity patterns in the monkey thalamus during visual behavior.
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DOI：
10.1152/jn.2000.84.4.1982
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发表时间：
2000-10
影响因子：
2.5
通讯作者：
E. Ramcharan;C. Cox;X. J. Zhan;S. Sherman;J. Gnadt
中科院分区：
文献类型：
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作者：
E. Ramcharan;C. Cox;X. J. Zhan;S. Sherman;J. Gnadt
我们首次通过体外记录显示，猴子丘脑中继细胞的突发放电是由电压依赖性低阈值Ca（2+）尖峰（LTSs）激活引起的，正如在其他哺乳动物中所描述的那样。由于LTS振幅的变化，LTS所诱发的动作电位的数量可以在1到8之间变化。这些数据证实了猴子丘脑中继细胞的两种放电模式的存在，紧张性和爆发性，后者与LTSs的激活有关。有了这些爆发放电的细胞过程的细节，我们可以解释我们从行为猴子的丘脑外侧膝状核记录到的许多放电模式。特别是，我们发现了清晰的证据表明，在清醒的状态下会有爆发性放电，而这一直被认为只发生在睡眠或某些病理状态下。这使得在清醒的人类中看到的突发放电可能具有与LTSs相同的细胞基础，这支持了先前的建议，即突发放电代表了视觉处理的重要中继模式。
We show for the first time with in vitro recording that burst firing in thalamic relay cells of the monkey is evoked by activation of voltage-dependent, low threshold Ca(2+) spikes (LTSs), as has been described in other mammals. Due to variations in LTS amplitude, the number of action potentials evoked by an LTS could vary between 1 and 8. These data confirm the presence of two modes of firing in the monkey for thalamic relay cells, tonic and burst, the latter related to the activation of LTSs. With these details of the cellular processes underlying burst firing, we could account for many of the firing patterns we recorded from the lateral geniculate nucleus of the thalamus in behaving monkeys. In particular, we found clear evidence of burst firing during alert wakefulness, which had been thought to occur only during sleep or certain pathological states. This makes it likely that the burst firing seen in awake humans has the same cellular basis of LTSs, and this supports previous suggestions that burst firing represents an important relay mode for visual processing.