Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members.
Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members.
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DOI：
10.1186/bcr327
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Olayioye MA
中科院分区：
文献类型：
--
作者：
Olayioye MA
ErbB（也称为HER）受体在上皮、间充质和神经元来源的各种组织中表达，其中它们参与控制多种生物过程，例如增殖、分化、迁移和凋亡。此外，它们的失调表达与许多类型的人类癌症有关，并且与不良的临床预后相关。由于ErbB蛋白在发育和细胞转化中的重要性，已经引起了人们对该受体酪氨酸激酶家族参与启动的细胞内信号的大量关注。这篇综述将集中在ErbB受体网络引发的近膜事件，并将解决受体异源二聚化如何可能有助于信号的规范和多样化的问题。
ErbB (also termed HER) receptors are expressed in various tissues of epithelial, mesenchymal and neuronal origin, in which they are involved in the control of diverse biological processes such as proliferation, differentiation, migration and apoptosis. Furthermore, their deregulated expression has been implicated in many types of human cancers and is associated with poor clinical prognosis. Owing to the importance of ErbB proteins in both development and cellular transformation, a lot of attention has been drawn to the intracellular signals initiated by the engagement of this family of receptor tyrosine kinases. This review will focus on the membrane proximal events triggered by the ErbB receptor network and will address questions of how receptor heterodimerization may contribute to signal specification and diversification.
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影响因子：
16.2
作者：
Huang, YZ;Won, S;Mei, L
通讯作者：
Mei, L
影响因子：
5.3
作者：
Fiorentino, L;Pertica, C;Segatto, O
通讯作者：
Segatto, O
影响因子：
3.3
作者：
Lesa, GM;Sternberg, PW
通讯作者：
Sternberg, PW
影响因子：
3.7
作者：
Olayioye, MA;Badache, A;Hynes, NE
通讯作者：
Hynes, NE
影响因子：
8
作者：
Neve, RM;Sutterlüty, H;Hynes, NE
通讯作者：
Hynes, NE