The Role of Decidual Natural Killer Cells in Normal Placentation and in the Pathogenesis of Preeclampsia
The Role of Decidual Natural Killer Cells in Normal Placentation and in the Pathogenesis of Preeclampsia
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DOI：
10.1016/s1701-2163(16)32862-6
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发表时间：
2008-06-01
影响因子：
1.8
通讯作者：
von Dadelszen, Peter
中科院分区：
文献类型：
--
作者：
Eastabrook, Genevieve;Hu, Yuxiang;von Dadelszen, Peter
在怀孕的最初几周内充分侵入人类胎盘是确保胎儿和孕产妇健康的关键一步。大量证据表明，蜕膜自然杀伤 (dNK) 细胞（一种独特的 CD56(bright)CD16(-) 淋巴细胞群）是这一复杂过程的关键调节因子。使用小鼠模型的实验和使用人体组织培养物的体外证据表明，dNK 细胞通过接触依赖性和接触非依赖性机制调节绒毛外滋养层 (EVT) 侵袭和母体螺旋动脉的重塑。此外，dNK 细胞表面受体的差异表达可能在着床和胎盘形成时通过调节母体免疫系统来决定生殖成功。 dNK 细胞分泌的细胞因子、趋化因子和生长因子的作用及其对 EVT 迁移、侵袭和假血管生成的影响尤其令人感兴趣。我们回顾了与胎盘时 dNK 细胞和滋养层之间的功能关系相关的现有实验证据，以阐明与人类病理学的潜在临床相关性，包括先兆子痫、复发性流产、IVF 失败和植入胎盘。
Adequate invasion of the human placenta during the first weeks of pregnancy is a critical step in ensuring both fetal and maternal health. A rapidly expanding body of evidence suggests that decidual natural killer (dNK) cells, a distinct population of CD56(bright)CD16(-) lymphocytes, are key regulators of this complex process. Experiments using murine models and in vitro evidence using human tissue cultures suggest that dNK cells modulate extravillous trophoblast (EVT) invasion and remodelling of maternal spiral arteries via both contact-dependent and contact-independent mechanisms. In addition, the differential expression of surface receptors by dNK cells may have a role in determining reproductive success through modulation of the maternal immune system at the time of implantation and placentation. The roles of cytokines, chemokines, and growth factors secreted by dNK cells and their influence on EVT migration, invasion, and pseudovasculogenesis are of particular interest. We reviewed the available experimental evidence related to the functional relationships between dNK cells and trophoblasts at the time of placentation to elucidate potential clinical correlations with human pathologies, including preeclampsia, recurrent pregnancy loss, IVF failure, and placenta accreta.