Voxel-based analysis of white matter during adolescence and young adulthood
Voxel-based analysis of white matter during adolescence and young adulthood
复制标题
基于体素的青春期和成年早期白质分析
DOI：
10.1016/j.braindev.2009.08.006
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发表时间：
2010-08-01
影响因子：
1.7
通讯作者：
Wang, Jiang
中科院分区：
文献类型：
--
作者：
Qiu, Mingguo;Li, Qiyu;Wang, Jiang
目的：通过对健康青少年和青壮年的体素分析，评估与年龄相关的脑白质的差异。材料和方法：对3组健康受试者(年龄分别为11~13岁、16~18岁和23~25岁)进行回波平面扩散张量磁共振成像。用线性相关分析确定年龄相关的分数各向异性(FA)和平均扩散系数(MD)，并用t检验比较不同年龄组之间FA和平均扩散图。结果：在内囊、外囊、额叶白质、膝体等部位，FA与年龄呈显著正相关。与11~13岁组相比，16~18岁组的内囊、额叶白质、体部和穹隆压部FA值增加。与16~18岁组相比，23~25岁组的额叶白质、内囊后肢、胼胝体膝部FA明显增加。在额叶和顶叶白质中，平均弥散系数与年龄呈显著负相关。与11~13岁组相比，16~18岁组的额叶前部和顶叶白质的MD降低。与16~18岁组相比，23~25岁组额叶白质MD降低。结论：磁共振扩散张量成像结果显示，不同年龄的脑白质成熟包括青春期和青春期脑白质的FA增加和平均弥散减少。FA和平均弥散可以反映健康青少年和青壮年不同的生理过程。综上所述，这些数据表明，白质的成熟是青春期和青春期大脑成熟的重要组成部分。(C)2009爱思唯尔B.V.保留所有权利。
Purpose: To evaluate differences in age-related brain white matter by voxel-based analysis of healthy adolescents and young adults. Materials and methods: Echo-planar diffusion-tensor magnetic resonance (MR) imaging was performed in healthy subjects of 3 groups (aged 11-13, 16-18 and 23-25, respectively). Linear correlative analyses were applied to determining age-related fractional anisotropy (FA) and mean diffusivity (MD), and t-test was performed to compare FA and mean diffusion maps between different age groups. Results: Significant positive correlation of FA with age was found in the internal capsule, the external capsule, the frontal white matter, and the body and genu of the corpus callosum. Compared with the 11-13 age group, FA in the 16-18 age group increased in the internal capsule, the frontal white matter, the body and the splenium of the corpus callosum. Compared to the 16-18 age group, FA in the 23-25 age group increased in the frontal white matter, the posterior limb of internal capsule, and the genu of the corpus callosum. Statistically significant negative correlation of the mean diffusion with age was found in the frontal and parietal white matter. Compared with the 11-13 age group, MD in the 16-18 age group decreased in the prefrontal and the temporo-parietal white matter. Compared with the 16-18 age group, MD in the 23-25 age group decreased in the frontal white matter. Conclusion: Diffusion-tensor MR imaging results indicate that white matter maturation assessed at different ages involves increases in FA and decreases in mean diffusion of the white matter during adolescence and young adulthood. FA and mean diffusion may reflect different physiologic processes in healthy adolescents and young adults. Taken together, these data show that maturation of white matter is an important part of brain maturation during adolescence and young adulthood. (C) 2009 Elsevier B.V. All rights reserved.