A LARGE DOMAIN COMMON TO SPERM RECEPTORS (ZP2 AND ZP3) AND TGF-BETA TYPE-III RECEPTOR
A LARGE DOMAIN COMMON TO SPERM RECEPTORS (ZP2 AND ZP3) AND TGF-BETA TYPE-III RECEPTOR
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DOI：
10.1016/0014-5793(92)80853-9
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发表时间：
1992-04-06
期刊：
影响因子：
3.5
通讯作者：
SANDER, C
中科院分区：
文献类型：
--
作者：
BORK, P;SANDER, C
通过序列分析定义了一个新的嵌合蛋白家族。该家族的特征是具有明显不同功能和组织特异性的蛋白质共有的 260 个残基结构域：精子受体 Zp2 和 Zp3、β 聚糖（也称为 TGF-β III 型受体）、尿调节素以及主要酶原颗粒膜蛋白 (GP-2)。共同结构域的位置与假定的跨膜区域相似。结果得出这样的假设：此类结构域具有共同的三级结构，并且精子受体系统和TGF-β受体复合物的识别机制具有功能相似性。
A new family of mosaic proteins is defined by sequence analysis. The family is characterized by a 260 residue domain common to proteins of apparently diverse function and tissue specificity: sperm receptors Zp2 and Zp3, betaglycan (also called TGF-beta type III receptor), uromodulin, as well as the major zymogen granule membrane protein (GP-2). The location of the common domain is similar with respect to putative transmembrane regions. The results lead to the hypothesis that this type of domain has a common tertiary structure and that there is a functional similarity in the recognition mechanism of the sperm receptor system and the TGF-beta receptor complex.