Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein
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DOI：
10.2337/diabetes.51.9.2734
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发表时间：
2002-09-01
期刊：
影响因子：
7.7
通讯作者：
Matsuzawa, Y
中科院分区：
文献类型：
--
作者：
Nishizawa, H;Shimomura, H;Matsuzawa, Y
脂联素是一种脂肪特异性分泌蛋白，具有抗糖尿病和抗动脉粥样硬化的作用。在本研究中，我们研究了性激素对脂联素产生的调节作用。442名男性（年龄52.6 ± 11.9岁[平均值+/- SD]）的血浆脂联素浓度显著低于137名女性（53.2 ± 12.0岁），但绝经前和绝经后女性之间无差异。在小鼠中，卵巢切除术并没有改变血浆脂联素水平。相反，高水平的血浆脂联素被发现在去势小鼠。替吉奥治疗降低了假手术和去势小鼠的血浆脂联素浓度。在3 T3-L1脂肪细胞中，睾酮减少脂联素分泌到培养基中，使用脉冲追踪研究。去势诱导的血浆脂联素升高与胰岛素敏感性显著改善相关。我们的研究结果表明雄激素降低血浆脂联素，雄激素诱导的低脂联素血症可能与男性胰岛素抵抗和动脉粥样硬化的高风险有关。
Adiponectin, an adipose-specific secretory protein, exhibits antidiabetic and antiatherogenic properties. In the present study, we examined the effects of sex hormones on the regulation of adiponectin production. Plasma adiponectin concentrations were significantly lower in 442 men (age, 52.6 +/- 11.9 years [mean +/- SD]) than in 137 women (53.2 +/- 12.0 years) but not different between pre- and postmenopausal women. In mice, ovariectomy did not alter plasma adiponectin levels. In contrast, high levels of plasma adiponectin were found in castrated mice. Testosterone treatment reduced plasma adiponectin concentration in both sham-operated and castrated mice. In 3T3-L1 adipocytes, testosterone reduced adiponectin secretion into the culture media, using pulse-chase study. Castration-induced increase in plasma adiponectin was associated with a significant improvement of insulin sensitivity. Our results indicate that androgens decrease plasma adiponectin and that androgen-induced hypoadiponectinemia may be related to the high risks of insulin resistance and atherosclerosis in men.