Estradiol, dopamine and motivation.
Estradiol, dopamine and motivation.
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DOI：
10.2174/1871524914666141226103135
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发表时间：
2014
影响因子：
--
通讯作者：
Becker JB
中科院分区：
文献类型：
--
作者：
Yoest KE;Cummings JA;Becker JB
性腺激素雌二醇调节雌性大鼠中脑边缘多巴胺系统。这种调节作用被认为是雌二醇对动机行为的影响的原因。多巴胺作用于伏隔核被认为是重要的诱因动机属性归因线索，预测奖励传递，而多巴胺在纹状体与重复或刻板行为的表达有关。雌二醇浓度的升高与性动机的增加或与获得配偶有关的线索有关，同时减弱了对食物的动机。这种动机显著性的转变对自然环境中的适应性选择行为很重要。此外，雌二醇对动机的适应性影响在增加非自然强化物（如滥用药物）的动机时可能不适应。在这里，我们讨论雌二醇对中脑端多巴胺传递的影响以及对动机行为的后续影响。雌二醇调节雌性大鼠的中脑边缘多巴胺系统，增强性动机，减弱食物动机。这种动机显著性的转变在自然环境中是适应性的。
The gonadal hormone estradiol modulates mesolimbic dopamine systems in the female rat. This modulatory effect is thought to be responsible for the observed effects of estradiol on motivated behaviors. Dopamine acting in the nucleus accumbens is thought to be important for the attribution of incentive motivational properties to cues that predict reward delivery, while dopamine in the striatum is associated with the expression of repetitive or stereotyped behaviors. Elevated concentrations of estradiol are associated with increased motivation for sex or cues associated with access to a mate, while simultaneously attenuating motivation for food. This shift in motivational salience is important for adaptive choice behavior in the natural environment. Additionally, estradiol’s adaptive effects on motivation can be maladaptive when increasing motivation for non-natural reinforcers, such as drugs of abuse. Here we discuss the effect of estradiol on mesotelencephalic dopamine transmission and subsequent effects on motivated behaviors. Estradiol modulates mesolimbic dopamine systems in the female rat, enhancing motivation for sex while attenuating motivation for food. This shift in motivational salience is adaptive in the natural environment.