Development of a Database for Translational Spinal Cord Injury Research
Development of a Database for Translational Spinal Cord Injury Research
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DOI：
10.1089/neu.2014.3399
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发表时间：
2014-11-01
影响因子：
4.2
通讯作者：
Ferguson, Adam R.
中科院分区：
文献类型：
--
作者：
Nielson, Jessica L.;Guandique, Cristian F.;Ferguson, Adam R.
近年来，在临床前水平对脊髓损伤（SCI）和其他复杂神经创伤疾病的了解取得了进展。然而，成功地将基础研究转化为临床实践一直很缓慢，部分原因是涉及的数据集庞大而异构。从这个意义上说，转化神经学研究代表了一个“大数据”问题。为了加速将临床前知识转化为脊髓损伤患者护理标准，我们描述了一个用于转化性神经创伤研究的新型数据库的开发，称为神经创伤-脊髓损伤的可视化综合征信息和结果（VISION-SCI）。我们目前正在努力建立一个多中心、多物种的SCI模型临床前数据库，并提出了人口统计学、描述性统计和转化综合征结果。我们利用了存档的手术记录、术后护理日志、行为结果测量和组织病理学，这些数据来自1993年至2013年间发表的临床前SCI研究中大约3000只小鼠、大鼠和猴子。数据库中的大多数动物都收集了用于健康监测的措施，如体重减轻/增加、心率、血压、术后膀胱功能监测和药物/液体管理、运动行为结果测量和死后组织保留。试图将这些变量与目前公认的共同数据元素结合起来，强调需要将更多的转化结果确定为治疗试验的临床终点。最后，我们使用综合征分析来确定大鼠和猴子之间颈椎脊髓损伤后恢复的保守生物学机制，这将允许更有效的治疗测试，这将需要转化为未来的临床试验。
Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of the large, heterogeneous data sets involved. In this sense, translational neurological research represents a "big data" problem. In an effort to expedite translation of pre-clinical knowledge into standards of patient care for SCI, we describe the development of a novel database for translational neurotrauma research known as Visualized Syndromic Information and Outcomes for Neurotrauma-SCI (VISION-SCI). We present demographics, descriptive statistics, and translational syndromic outcomes derived from our ongoing efforts to build a multi-center, multi-species pre-clinical database for SCI models. We leveraged archived surgical records, postoperative care logs, behavioral outcome measures, and histopathology from approximately 3000 mice, rats, and monkeys from pre-clinical SCI studies published between 1993 and 2013. The majority of animals in the database have measures collected for health monitoring, such as weight loss/gain, heart rate, blood pressure, postoperative monitoring of bladder function and drug/fluid administration, behavioral outcome measures of locomotion, and tissue sparing postmortem. Attempts to align these variables with currently accepted common data elements highlighted the need for more translational outcomes to be identified as clinical endpoints for therapeutic testing. Last, we use syndromic analysis to identify conserved biological mechanisms of recovery after cervical SCI between rats and monkeys that will allow for more-efficient testing of therapeutics that will need to be translated toward future clinical trials.