Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms.
Bone-Protective Effects of Dried Plum in Postmenopausal Women: Efficacy and Possible Mechanisms.
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DOI：
10.3390/nu9050496
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发表时间：
2017-05-14
期刊：
影响因子：
5.9
通讯作者：
Akhavan NS
中科院分区：
文献类型：
--
作者：
Arjmandi BH;Johnson SA;Pourafshar S;Navaei N;George KS;Hooshmand S;Chai SC;Akhavan NS
骨质疏松症是一种与年龄相关的慢性疾病，其特征是骨量和质量的丧失，并与脆性骨折的风险增加有关。绝经后妇女患骨质疏松症的风险最大，因为卵巢激素分泌停止，导致加速骨质流失。随着人口结构向老龄化人口转变，越来越多的绝经后妇女将受到骨质疏松症的困扰。众所周知，某些生活方式因素，包括营养和锻炼，可以降低患骨质疏松症的风险，因此对骨骼健康起着重要作用。在营养方面，越来越多的证据表明，李干(Prunus home tica L.)在去卵巢的骨质疏松大鼠模型中，以及在骨量减少的绝经后妇女中，该药物可能是预防和逆转骨量和结构丢失的有效干预措施。在这里，我们提供了证据支持干李子在预防和逆转与卵巢激素缺乏相关的骨丢失的有效性，在啮齿动物模型和人类中。我们以最近一项跟踪研究的结果结束，该研究表明，在五年前进行的为期一年的临床试验中，以前每天食用100克梅干的绝经后妇女比接受比较控制的妇女保留骨密度的程度更大。此外，我们强调了李干中的生物活性化合物发挥骨保护作用的可能作用机制。总体而言，我们的研究结果和其他研究结果强烈表明，完整形式的李干是一种有前途的、有效的功能食品疗法，可以预防绝经后妇女的骨丢失，具有长期骨保护作用的潜力。
Osteoporosis is an age-related chronic disease characterized by a loss of bone mass and quality, and is associated with an increased risk of fragility fractures. Postmenopausal women are at the greatest risk of developing osteoporosis due to the cessation in ovarian hormone production, which causes accelerated bone loss. As the demographic shifts to a more aged population, a growing number of postmenopausal women will be afflicted with osteoporosis. Certain lifestyle factors, including nutrition and exercise, are known to reduce the risk of developing osteoporosis and therefore play an important role in bone health. In terms of nutrition, accumulating evidence suggests that dried plum (Prunus domestica L.) is potentially an efficacious intervention for preventing and reversing bone mass and structural loss in an ovariectomized rat model of osteoporosis, as well as in osteopenic postmenopausal women. Here, we provide evidence supporting the efficacy of dried plum in preventing and reversing bone loss associated with ovarian hormone deficiency in rodent models and in humans. We end with the results of a recent follow-up study demonstrating that postmenopausal women who previously consumed 100 g dried plum per day during our one-year clinical trial conducted five years earlier retained bone mineral density to a greater extent than those receiving a comparative control. Additionally, we highlight the possible mechanisms of action by which bioactive compounds in dried plum exert bone-protective effects. Overall, the findings of our studies and others strongly suggest that dried plum in its whole form is a promising and efficacious functional food therapy for preventing bone loss in postmenopausal women, with the potential for long-lasting bone-protective effects.