Synthesis of double C-glycoside analogue of sTn.
Synthesis of double C-glycoside analogue of sTn.
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DOI：
10.1021/jo050691n
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发表时间：
2005-09
期刊：
影响因子：
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通讯作者：
D. Ress;S. Baytas;Qun Wang;E. Muñoz;Kazuo Tokuzoki;H. Tomiyama;R. Linhardt
中科院分区：
文献类型：
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作者：
D. Ress;S. Baytas;Qun Wang;E. Muñoz;Kazuo Tokuzoki;H. Tomiyama;R. Linhardt
利用钐化学法合成了一种sTn双C-糖苷，sTn类似物2。采用酰胺的双重保护和室温离子液体作溶剂，克服了醛受体氧化反应的复杂性。目前正在研究将sTn双C-糖苷半抗原2与KLH载体蛋白偶联，用于作为疫苗的生物学评价。
A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.