Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers.
Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers.
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DOI：
10.4103/0019-5278.34529
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发表时间：
2007-05-01
影响因子：
0.9
通讯作者：
Masheyi, Olatunde O
中科院分区：
文献类型：
--
作者：
Banjoko, Sunny O;Sridhar Mynapelli, K C;Masheyi, Olatunde O
二氯甲烷（MeCl（2））是一种无色透明、挥发性、气味芳香、亲脂性的溶剂，用作木器漆和油漆的成分。人体接触主要是由于吸入，其通过肝脏混合功能氧化酶（MFO）的生物转化导致一氧化碳（CO）的形成。同时暴露于MeCl（2）和增加的环境CO会导致不期望的碳氧血红蛋白（COHb）形成增加，这容易导致碳氧血红蛋白血症，中枢神经系统是毒性的主要靶器官。在尼日利亚伊巴丹的不同过去和50名橱柜制造商的工作场所微环境中，使用CO个人监测仪测定了环境CO水平50名志愿者（对照组）和50名非家具制造职业的志愿者（实验组）。Mann Whitney U和Kruskaal沃利斯是使用的统计分析方法。对两组进行了测试。用差示分光光度法测定了两组个体静脉血中的碳氧血红蛋白水平。观察到伊巴丹的环境CO水平在4和52 ppm之间，平均值为20 ppm。作业环境中CO浓度分别为5.2 ± 1.08ppm和2.08 ± 0.91ppm，显著高于对照组（P
Methylene chloride (MeCl(2)) is a clear colorless volatile sweet smelling lipophilic solvent used as a constituent of wood vanishes and paints. Human exposure is mainly due to inhalation and its biotransformation by the hepatic mixed function oxidases (MFO) leads to formation of carbon monoxide (CO). Simultaneous exposure to MeCl(2) and increased ambient CO results in undesirably increased carboxyhemoglobin (COHb) formation, which predisposes to carboxyhemoglobinaemia with the central nervous system as the primary target organ of toxicity.In this study, ambient CO levels were determined using a CO personal monitor in different pasts of Ibadan Nigeria and work place microenvironment of 50 Cabinet makers (test group) and 50 volunteer (control) in non-furniture making occupations. Mann Whitney U and Kruskaal Wallis were the statistical methods of analysis used.Questionnaires were administered to both groups carboxyhaemoglobin levels were determined in venous blood drawn from individuals in the two groups by differential spectrophotometric method.Ambient CO levels in Ibadan were observed to be between 4 and 52 ppm with a mean of 20 ppm. Work environment CO levels were significantly higher in test subjects than controls at 5.2 ± 1.08 ppm and 2.08 ± 0.91 ppm respectively (P