The dicey role of Dicer: implications for RNAi therapy.
The dicey role of Dicer: implications for RNAi therapy.
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DOI：
10.1158/0008-5472.can-09-2536
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发表时间：
2010-04-01
期刊：
影响因子：
11.2
通讯作者：
Sood AK
中科院分区：
文献类型：
--
作者：
Merritt WM;Bar-Eli M;Sood AK
RNA干扰（RNAi）在肿瘤生物学中的动态特性使研究人员对其在肿瘤发生和癌症治疗中的作用产生了极大的兴趣。我们最近报道了上皮性卵巢癌中关键RNAi酶Dicer和Drosha的表达降低与患者的不良临床结局相关。Dicer表达在功能上也是相关的，因为与不需要Dicer功能的RNAi片段相比，需要Dicer功能的RNAi片段限制了靶向沉默。总之，这项研究和其他研究表明，RNAi机制的表达可能会影响肿瘤发生和癌症生物学的关键途径。了解功能性RNAi机制的改变对于我们努力开发使用RNAi策略的新疗法至关重要。
The dynamic properties of RNA interference (RNAi) in cancer biology have led investigators to pursue with significant interest its role in tumorigenesis and cancer therapy. We recently reported that decreased expression of key RNAi enzymes, Dicer and Drosha, in epithelial ovarian cancers was associated with poor clinical outcome in patients. Dicer expression was also functionally relevant in that targeted silencing was limited with RNAi fragments that require Dicer function compared with those that do not. Together, this and other studies suggest that RNAi machinery expression may affect key pathways in tumorigenesis and cancer biology. Understanding alterations in the functional RNAi machinery is of fundamental importance as we strive to develop novel therapies using RNAi strategies.