Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats
Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats
复制标题
天竺葵苷对大鼠卵巢切除所致骨丢失的骨保护作用
DOI：
10.1016/j.bmcl.2014.11.081
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发表时间：
2015-02-01
影响因子：
2.7
通讯作者：
Shen, Zhiqiang
中科院分区：
文献类型：
--
作者：
Lu, Yiqin;He, Bo;Shen, Zhiqiang
本研究观察了老鹳草素对去卵巢大鼠骨质疏松的防治作用。生化指标分析表明，老鹳草素可显著升高血清钙、雌二醇和降钙素水平，降低血清碱性磷酸酶、抗酒石酸酸性磷酸酶、I型胶原C端肽和尿脱氧吡啶啉/肌酐比值水平。与去卵巢组相比，老鹳草素能预防去卵巢引起的骨密度和骨矿含量的降低，提高股骨重量和骨钙含量，增强骨力学性能。此外，天竺葵素被证明可以改善OVX诱导的骨丢失的组织形态学参数，包括骨小梁数量、厚度和分离。这些结果表明，老鹳草素对OVX诱导的大鼠骨质疏松症具有保护作用。(C)2014爱思唯尔有限公司版权所有。
In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis. (C) 2014 Elsevier Ltd. All rights reserved.