Non-transmembrane PTPs in Cancer
Non-transmembrane PTPs in Cancer
复制标题
DOI：
10.1007/978-1-4939-3649-6_3
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
W. Hendriks;F. Böhmer
中科院分区：
文献类型：
--
作者：
W. Hendriks;F. Böhmer
在本章中，我们将讨论14种非跨膜（NT）型蛋白酪氨酸磷酸酶（PTPs，由基因PTPN 3、PTPN 4、PTPN 5、PTPN 6、PTPN 7、PTPN 9、PTPN 13、PTPN 14、PTPN 18、PTPN 20、PTPN 21、PTPN 22、PTPN 23和PTPRR编码）在癌症中的作用。NTPTPs的介绍包括对单个分子在结构和活性调节方面的一般特征的简要描述，以及关于其生理功能的关键事实。随后讨论了癌细胞中NTPTP基因的遗传或表观遗传改变，以及特定表型效应的分子后果。PTPN 6、PTPN 13或PTPN 23功能缺陷在某些肿瘤类型中的作用已被最好地确定。对于其他NTPTP，癌症中假定作用的指征取决于癌组织中的基因突变、NTPTP状态改变的细胞系的表型和已知的生理功能，但需要在未来的研究中确认。显然，NTPTP对癌症表型的作用取决于特定的细胞环境。NTPTPs在癌症微环境和抗癌药物治疗反应中的作用正在显现。NTPTPs在免疫细胞中的功能，特别是PTPN 6，也可能允许未来的治疗开发。
In this chapter, we will discuss the role of 14 non-transmembrane (NT) type protein-tyrosine phosphatases (PTPs, encoded by the genesPTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN13, PTPN14, PTPN18, PTPN20, PTPN21, PTPN22, PTPN23, andPTPRR) in cancer. The presentation of NTPTPs includes a brief description of general features of the individual molecules in structure and activity regulation, as well as key facts about their physiological functions. Genetic or epigenetic alterations of NTPTP genes in cancer cells and, if available, the molecular consequences for the specific phenotypic effects are subsequently discussed. A role for defects of PTPN6, PTPN13, or PTPN23 function in certain tumor types has been established best. For other NTPTPs, indications for putative roles in cancer rest on gene mutations in cancer tissues, phenotypes of cell lines with altered NTPTP status, and known physiological functions, but need confirmation in future studies. Clearly, NTPTP effects on cancer phenotypes are dependent on the specific cell context. Roles of NTPTPs in the cancer microenvironment and for therapeutic responses to anti-cancer drugs are emerging. Functions of NTPTPs in immune cells, notably of PTPN6, might also allow therapeutic exploitation in the future.