Is testosterone deficiency a possible risk factor for priapism associated with sickle-cell disease?
Is testosterone deficiency a possible risk factor for priapism associated with sickle-cell disease?
复制标题
DOI：
10.1007/s11255-014-0864-1
复制
发表时间：
2015-01-01
影响因子：
2
通讯作者：
Burnett, Arthur L.
中科院分区：
文献类型：
--
作者：
Morrison, Belinda F.;Anele, Uzoma A.;Burnett, Arthur L.
本研究的目的是确定睾酮缺乏和勃起与镰状细胞病(SCD)的关系。对50例SCD(血红蛋白SS)的成年男性进行了横断面研究。所有患者清晨采血测定总睾酮、游离睾酮、卵泡刺激素、促黄体生成素、催乳素、血脂、乳酸脱氢酶和血液学指标。患者完成了面试者管理的关于异常勃起频率、持续时间和治疗的问卷调查。睾酮缺乏症定义为血清总睾酮+12nmol/L(346 ng/dL)。研究人群的平均年龄为34.2+/-A8.9岁。异常勃起发生在24例(48%)患者中，多见于18-25岁的男性。50名患者中有11名(22%)出现睾酮缺乏，尤其是有异常勃起病史的24名患者中有6名(25%)。有异常勃起病史和无异常勃起病史患者的平均总睾酮水平分别为16.7+/-A4.9nmol/L和15.4+/-A5.9nmol/L，差异无统计学意义(P=0.43)。类似地，异常勃起病史对血清黄体生成素和卵泡刺激素水平没有影响。睾酮缺乏在SCD患者中普遍存在；然而，我们没有发现基于异常勃起病史的相关性。需要更大的、前瞻性收集的数据来确定伴有睾酮缺乏的SCD患者的异常勃起情况。
The purpose of this study was to determine the association of testosterone deficiency and priapism in adult men with sickle cell disease (SCD).A cross-sectional study of 50 adult men with SCD (hemoglobin SS) was performed. All patients had early morning blood taken for total and free testosterone, FSH, LH, prolactin, lipid levels, LDH and hematological indices. Patients completed an interviewer-administered questionnaire regarding priapism frequency, duration and treatment. Testosterone deficiency was defined as a serum total testosterone < 12 nmol/L (346 ng/dL).The mean age of the study population was 34.2 +/- A 8.9 years. Priapism was noted in 24 (48 %) patients and was most frequently seen in men between ages 18-25 years. Testosterone deficiency was observed in 11 of the 50 (22 %) patients, particularly in 6 of 24 (25 %) patients with histories of priapism. There was no difference in mean total testosterone levels in patients with and without a history of priapism (16.7 +/- A 4.9 nmol/L and 15.4 +/- A 5.9 nmol/L, respectively) (p = 0.43). Similarly, there was no difference in serum LH and FSH levels based on history of priapism.Testosterone deficiency is prevalent in patients with SCD; however, we did not identify an association based on a history of priapism. Larger, prospectively gathered data are needed to define the priapism profile of SCD patients with testosterone deficiency.