Functional characterization of the dendritically localized mRNA neuronatin in hippocampal neurons.
Functional characterization of the dendritically localized mRNA neuronatin in hippocampal neurons.
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DOI：
10.1371/journal.pone.0024879
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Poon MM
中科院分区：
文献类型：
--
作者：
Oyang EL;Davidson BC;Lee W;Poon MM
树突状mRNA的局部翻译在神经元发育和突触可塑性中起着重要作用。虽然已经确定了几百个假定的树突状转录在海马，相对较少的已被证实原位杂交，因此仍然没有特征。一种这样的转录物编码神经元蛋白。神经元素已被证明可以调节非神经元细胞（如胰腺或胚胎干细胞）中的钙水平，但其在成熟神经元中的功能仍不清楚。在这里，我们报告说，神经元蛋白的翻译海马树突的动作电位和NMDA受体依赖性突触传递的TTX和APV的封锁作出反应。我们的研究还表明，neuronatin可以通过调节细胞内钙储存来调节树突钙水平。我们认为neuronatin可能通过调节稳态可塑性过程中树突状细胞的钙水平来影响突触可塑性，从而潜在地调节神经元的兴奋性、受体运输和钙依赖性信号传导。
Local translation of dendritic mRNAs plays an important role in neuronal development and synaptic plasticity. Although several hundred putative dendritic transcripts have been identified in the hippocampus, relatively few have been verified by in situ hybridization and thus remain uncharacterized. One such transcript encodes the protein neuronatin. Neuronatin has been shown to regulate calcium levels in non-neuronal cells such as pancreatic or embryonic stem cells, but its function in mature neurons remains unclear. Here we report that neuronatin is translated in hippocampal dendrites in response to blockade of action potentials and NMDA-receptor dependent synaptic transmission by TTX and APV. Our study also reveals that neuronatin can adjust dendritic calcium levels by regulating intracellular calcium storage. We propose that neuronatin may impact synaptic plasticity by modulating dendritic calcium levels during homeostatic plasticity, thereby potentially regulating neuronal excitability, receptor trafficking, and calcium dependent signaling.
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影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
影响因子：
5.3
作者：
Huang, F;Chotiner, JK;Steward, O
通讯作者：
Steward, O
影响因子：
5.3
作者：
Grooms, Sonja Y.;Noh, Kyung-Min;Zukin, R. Suzanne
通讯作者：
Zukin, R. Suzanne
DOI：
10.1073/pnas.0905110106
发表时间：
2009-09-01
影响因子：
11.1
作者：
Holbro, Niklaus;Grunditz, Asa;Oertner, Thomas G.
通讯作者：
Oertner, Thomas G.
影响因子：
16.2
作者：
Campbell, DS;Holt, CE
通讯作者：
Holt, CE