GENDER DIFFERENCES IN CYSTIC-FIBROSIS - PSEUDOMONAS-AERUGINOSA INFECTION
GENDER DIFFERENCES IN CYSTIC-FIBROSIS - PSEUDOMONAS-AERUGINOSA INFECTION
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DOI：
10.1016/0895-4356(94)00230-n
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发表时间：
1995-08-01
影响因子：
7.2
通讯作者：
DAVIS, PB
中科院分区：
文献类型：
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作者：
DEMKO, CA;BYARD, PJ;DAVIS, PB
女性囊性纤维化（CF）患者的中位生存年龄比男性约小3岁。我们测试了女性CF患者早期获得铜绿假单胞菌（PA）或该生物体对其肺部疾病的更大影响，或两者兼而有之，是否导致其生存率降低。分析了在我们中心随访至少2年、每年至少进行3次呼吸道培养的患者的PA感染状态、生存率、肺功能检查和胸部X线评分（n = 848）。粘液PA慢性感染的中位年龄女性比男性早1.7年。感染粘液PA的患者比没有假单胞菌或只有非粘液表型的患者的生存率、胸部X线评分和肺功能检查更差。获得粘液PA与肺功能下降速度加快相关。然而，粘液PA感染后肺功能的变化率男性和女性相似。此外，即使在只有粘液型或只有非粘液型的患者中，男性也有更好的1秒用力呼气量预测百分比和更好的生存率。因此，除了早期获得粘液PA的因素可能有助于女性CF患者的生存率较差。
The median survival age for females with cystic fibrosis (CF) is approximately 3 years younger than for males. We tested whether earlier acquisition of Pseudomonas aeruginosa (PA) by female CF patients or the greater impact of this organism on their lung disease, or both, contribute to their poorer survival. PA infection status, survival, pulmonary function tests, and chest X-ray scores from patients who were followed at our center for at least 2 years with a minimum of three respiratory cultures per year were analyzed (n = 848). The median age of chronic infection with mucoid PA was 1.7 years earlier in females than in males. Patients infected with mucoid PA had poorer survival, chest X-ray scores, and pulmonary function tests than patients who had either no Pseudomonas species or only the nonmucoid phenotype. Acquisition of mucoid PA was associated with an accelerated rate of decline in pulmonary function. However, the rate of change of pulmonary function after mucoid PA infection was similar for males and females. Moreover, even among patients who had only the mucoid form or only the nonmucoid form, males had better percent predicted forced expiratory volume in 1 sec and better survival. Therefore, factors in addition to earlier acquisition of mucoid PA may contribute to the poorer survival of female CF patients.