Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women:: interactions with genotype and equol production
Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women:: interactions with genotype and equol production
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DOI：
10.1093/ajcn/82.6.1260
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发表时间：
2005-12-01
影响因子：
7.1
通讯作者：
Williams, CM
中科院分区：
文献类型：
--
作者：
Hall, WL;Vafeiadou, K;Williams, CM
背景：由于结构上与雌激素相似，膳食中的胆甾酮被认为具有心脏保护作用。雌激素降低循环炎症标志物的浓度可能是绝经前妇女预防心血管疾病的机制之一。目的：我们的目的是研究分离的大豆异黄酮对炎症生物标志物[血管性血友病因子，细胞内粘附分子1，血管细胞粘附分子1（VCAM-1），E-选择素，单核细胞趋化蛋白1，C-反应蛋白（CRP）和内皮素1浓度]。选择性基因[雌激素受体α]单核苷酸多态性的差异（XbaI和PvuII）、雌激素受体β [ER β（TbaI）和ER β [cx]（Tsp 5091）、内皮型一氧化氮合酶（Glu 298 Asp），载脂蛋白E研究了[载脂蛋白E2、E3和E4]和胆固醇酯转移蛋白（TaqIB）]和雌马酚的生产。117名健康的欧洲绝经后妇女参加了这项随机、双盲、安慰剂对照、交叉饮食干预试验。富含异黄酮（染料木黄酮与大豆苷元的比例为2：1;50 mg/d）或安慰剂谷物棒食用8周，交叉之间的洗脱期为8周。在每个研究组0周和8周时测量血浆炎症因子。结果：异黄酮改善了CRP浓度[异黄酮与安慰剂相比，CRP值>1 mg/L的比值比（95%CI）：0.43（0.27，0.69）];未观察到异黄酮治疗对其他血浆炎症标志物的显着影响。根据雌马酚生产的亚组，观察到对雌马酮的反应无显著差异。在VCAM-1的反应与ER β GRI 1 genotype.Conclusion. Isoflavones有有益的影响CRP浓度，但不是对其他炎症生物标志物的心血管疾病的风险在绝经后妇女，并可能改善VCAM-1的ER β基因多态性亚组。
Background: Dietary isoflavones are thought to be cardioprotective because of their structural similarity to estrogen. The reduction of concentrations of circulating inflammatory markers by estrogen may be one of the mechanisms by which premenopausal women are protected against cardiovascular disease.Objective: Our aim was to investigate the effects of isolated soy isoflavones on inflammatory biomarkers [von Willebrand factor, intracellular adhesion molecule 1, vascular cell adhesion molecule 1 (VCAM-1), E-selectin, monocyte chemoattractant protein 1, C-reactive protein (CRP), and endothelin 1 concentrations]. Differences with respect to single-nucleotide polymorphisms in selected genes [estrogen receptor alpha (XbaI and PvuII), estrogen receptor beta [ER beta (AluI) and ER beta[cx] (Tsp5091), endothelial nitric oxide synthase (Glu298Asp), apolipoprotein E (Apo E2, E3, and E4), and cholesteryl ester transfer protein (TaqIB)] and equol production were investigated.Design: One hundred seventeen healthy European postmenopausal women participated in this randomized, double-blind, placebo-controlled, crossover dietary intervention trial. Isoflavone-enriched (genistein-to-daidzein ratio of 2:1;50 mg/d) or placebo cereal bars were consumed for 8 wk, with a washout period of 8 wk between the crossover. Plasma inflammatory factors were measured at 0 and 8 wk of each study arm.Results: Isoflavones improved CRP concentrations [odds ratio (95% Cl) for CRP values >1 mg/L for isoflavone compared with placebo: 0.43 (0.27, 0.69)]; no significant effects of isoflavone treatment on other plasma inflammatory markers were observed. No significant differences in the response to isoflavones were observed according to subgroups of equol production. Differences in the VCAM-1 response to isoflavones and to placebo were found with ER beta AluI genotypes.Conclusion: Isoflavones have beneficial effects on CRP concentrations, but not on other inflammatory biomarkers of cardiovascular disease risk in postmenopausal women, and may improve VCAM-1 in an ER beta gene polymorphic subgroup.