Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura.
Serum IgG subclasses and IgM imbalances in adult IgA mesangial glomerulonephritis and idiopathic Henoch-Schoenlein purpura.
复制标题
成人 IgA 系膜肾炎和特发性过敏性紫癜的血清 IgG 亚类和 IgM 失衡。
DOI：
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发表时间：
1989
影响因子：
4.6
通讯作者：
G. Lagrue
中科院分区：
文献类型：
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作者：
G. Rostoker;M. Pech;S. Del Prato;M. Petit;A. Ben Maadi;J. Dubert;P. Lang;B. Weil;G. Lagrue
应用单克隆抗体检测27例IgA GN和HSP患者及19例健康配对对照者血清IgG亚类水平。在非肾病和肾病患者中，IgG1和IgG2均低于对照组，80%的非肾病患者表现出IgG1、IgG2或IgG3的部分缺乏。尿中IgG的丢失只导致IgG4水平的降低。54%的患者表现出IgM水平下降。这种IgG-IgM失衡可能增加这些患者对上呼吸道病毒和细菌感染的易感性，并引发肾脏疾病。这些发现提出了一种假说，即这种IgG-IgM失衡可能参与了这些疾病的发病机制。
Serum IgG subclass levels were investigated in 27 IgA GN and HSP patients and 19 healthy paired controls using a panel of monoclonal antibodies. IgG1 and IgG2 were statistically lower than in the controls in both the non-nephrotic and nephrotic patients, and 80% of the non-nephrotic patients exhibited a partial deficiency for either IgG1, IgG2 or IgG3. Urinary losses of IgG only accounted for decreased levels of IgG4. Fifty-four percent of these patients exhibited decreased IgM levels. This IgG-IgM imbalance may increase the susceptibility of these patients to viral and bacterial infections of the upper respiratory tract and trigger the renal disease. These findings raise the hypothesis that this IgG-IgM imbalance might be involved in the etiopathogenesis of these diseases.