C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma.
C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma.
复制标题
患有纤维肉瘤的绒毛猴（Lagothrix spp.）肿瘤组织中的 C 型病毒。
DOI：
10.1093/jnci/47.4.881
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
D. Dungworth
中科院分区：
文献类型：
--
作者：
G. Theilen;D. Gould;M. Fowler;D. Dungworth
一只3岁的雄性毛猴因多发性纤维肉瘤和骨髓纤维化伴髓样化生被送到兽医教学医院。随后的超微结构研究显示C型病毒颗粒从肿瘤和骨髓组织中的成纤维细胞、组织细胞型细胞和细胞碎片复制。未成熟和成熟的病毒粒子经常被发现在细胞外空间。这些病毒体在形态上与鸡、小鼠和猫的白血病-肉瘤复合体相似。
A 3-year-old male woolly monkey was presented to the Veterinary Teaching Hospital with multiple fibrosarcomas and myelofibrosis with myeloid metaplasia. Subsequent ultrastructural investigations revealed C-type viral particles replicating from fibroblasts, histiocyte-type cells, and cell fragments in tumor and bone marrow tissue. Immature and mature virions frequently were found in extracellular spaces. These virions were morphologically similar to those associated with the leukemia-sarcoma complex of chickens, mice, and cats.