A Population Study of Childhood Maltreatment and Asthma Diagnosis: Differential Associations Between Child Protection Database Versus Retrospective Self-Reported Data
A Population Study of Childhood Maltreatment and Asthma Diagnosis: Differential Associations Between Child Protection Database Versus Retrospective Self-Reported Data
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DOI：
10.1097/psy.0b013e3182648de4
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发表时间：
2012-10-01
影响因子：
3.3
通讯作者：
Ellis, Pete M.
中科院分区：
文献类型：
--
作者：
Scott, Kate M.;Smith, Don A. R.;Ellis, Pete M.
尽管越来越多的纵向研究证明了早期生活压力和哮喘的发生之间的联系，但很少有人研究最严重的早期生活压力之一：童年虐待。关于这一主题的横断面研究依赖于虐待的回顾性自我报告。本研究调查了儿童保护机构记录与自我报告显示的儿童期虐待与年轻人终身哮喘诊断之间的关联，调整了社会经济地位和精神状况。紊乱研究方法：在新西兰进行的一项具有全国代表性的DSM-IV精神障碍一般人群调查（n = 12，992）获得了关于慢性身体状况终身诊断的信息。从16至27岁的调查受访者（n = 1413）的子样本的信息与国家儿童保护数据库，以确定受访者的机构参与的历史，这是用来作为儿童虐待的代理。还获得了关于虐待的回顾性报告。结果如下：儿童保护机构的病史与终生诊断为哮喘的几率升高相关（比值比= 2.88 [95%置信区间= 1.7-4.74]）。在调整了社会经济状况、终生精神障碍、终生吸烟和体重指数等各种指标后，这种关联仍然显著升高（比值比= 2.26 [95%置信区间= 1.33-3.83]）。儿童时期的虐待与哮喘无关。结论：儿童期虐待与哮喘诊断几率升高有关。这些发现与早期生活压力可能是增加遗传易感个体患哮喘风险的环境因素之一的可能性一致。
Despite growing evidence from longitudinal studies of a link between early-life stress and the development of asthma, very few of these examine one of the most severe types of early-life stress: childhood maltreatment. Cross-sectional studies on this topic have relied on retrospective self-reports of maltreatment. This study investigates associations between childhood maltreatment indicated by child protection agency records versus self-reports and lifetime asthma diagnosis in young adults, adjusting for socioeconomic status and mental. disorders. Methods: A nationally representative general population survey of DSM-IV mental disorders in New Zealand (n = 12,992) obtained information on lifetime diagnoses of chronic physical conditions. Information from a subsample of survey respondents aged 16 to 27 years (n = 1413) was linked with a national child protection database to identify respondents with a history of agency involvement, which was used as a proxy for childhood maltreatment. Retrospective reports of maltreatment were also obtained. Results: Child protection agency history was associated with elevated odds (odds ratio = 2.88 [95% confidence interval = 1.7-4.74]) of a lifetime diagnosis of asthma. After adjusting for a variety of indicators of socioeconomic status, lifetime mental disorders, lifetime smoking, and body mass index, this association remained significantly elevated (odds ratio = 2.26 [95% confidence interval = 1.33-3.83]). Retrospectively self-reported maltreatment in childhood was not associated with asthma. Conclusions: Childhood maltreatment was associated with elevated odds of asthma diagnosis. These findings are consistent with the possibility that early-life stress may be one of the environmental factors that increase the risk of asthma in genetically vulnerable individuals.