Nucleotide sequence analysis of a provirus derived from HTLV-1-associated myelopathy (HAM).
Nucleotide sequence analysis of a provirus derived from HTLV-1-associated myelopathy (HAM).
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源自 HTLV-1 相关脊髓病 (HAM) 的原病毒的核苷酸序列分析。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
M. Miwa
中科院分区：
文献类型：
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作者：
A. Tsujimoto;T. Teruuchi;J. Imamura;K. Shimotohno;I. Miyoshi;M. Miwa
已知人类 T 细胞白血病病毒 1 型 (HTLV-1) 与成人 T 细胞白血病 (ATL) 有关。最近，HTLV-1 相关性脊髓病 (HAM) 被描述为一种神经系统疾病，怀疑与 HTLV-1 存在病因学关联。为了详细检查与 HAM 相关的病原病毒，从 HAM 患者脑脊液中的淋巴细胞系中克隆了原病毒基因组。原病毒的长末端重复(LTR)、蛋白酶、env和pX区的核苷酸序列与源自ATL的HTLV-1的核苷酸序列显示出超过97%的同源性。这些结果表明，这种源自 HAM 患者的原病毒与源自 ATL 患者的 HTLV-1 属于同一物种。
Human T-cell leukemia virus type 1 (HTLV-1) is known to be associated with adult T-cell leukemia (ATL). Recently, HTLV-1-associated myelopathy (HAM) was described as a neurological disease with which an etiological association of HTLV-1 is suspected. A provirus genome was cloned from a lymphoid cell line derived from the cerebrospinal fluid of a patient with HAM, in order to examine in detail the etiological virus associated with HAM. The nucleotide sequence of the long terminal repeat (LTR), protease, env and pX regions of the provirus shows over 97% homology with that of HTLV-1 derived from ATL. These results suggest that this provirus, derived from a patient with HAM, belongs to the same species as HTLV-1 derived from patients with ATL.