Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making
Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision making
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DOI：
10.1101/lm.409306
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发表时间：
2006-11-01
影响因子：
2
通讯作者：
Hauber, Wolfgang
中科院分区：
文献类型：
--
作者：
Schweimer, Judith;Hauber, Wolfgang
前扣带皮层（ACC）参与编码一个动作是否值得执行，考虑到执行该动作的预期收益和成本。对ACC的多巴胺输入可能对这种基于努力的决策形式至关重要;然而，不同ACC多巴胺受体的作用尚不清楚。因此，我们在大鼠中研究了内ACC D1和D2受体阻断对T型迷宫成本效益任务中测试的基于努力的决策的影响。在这项任务中，受试者可以选择爬上障碍物，在一只手臂上获得高奖励，或者在没有障碍物的另一只手臂上获得低奖励。与溶剂处理的大鼠不同，当大鼠在ACC内输注D1受体拮抗剂SCH 23390时，在选择以很少的努力获得低奖励时，表现出对高成本高奖励反应选项的偏好降低。相比之下，在大鼠内ACC输注的D2受体拮抗剂依替氯必利，高成本高回报的反应选项的偏好没有改变相对于车辆治疗的大鼠。这些数据提供了第一个证据表明，D1受体在ACC调节努力为基础的决策。
The anterior cingulate cortex (ACC) has been implicated in encoding whether or not an action is worth performing in view of the expected benefit and the cost of performing the action. Dopamine input to the ACC may be critical for this form of effort-based decision making; however, the role of distinct ACC dopamine receptors is yet unknown. Therefore, we examined in rats the effects of an intra-ACC D1 and D2 receptor blockade on effort-based decision making tested in a T-maze cost-benefit task. In this task, subjects could either choose to climb a barrier to obtain a high reward in one arm or a low reward in the other arm without a barrier. Unlike vehicle-treated rats, rats with intra-ACC infusion of the D1 receptor antagonist SCH23390 exhibited a reduced preference for the high-cost high-reward response option when having the choice to obtain a low reward with little effort. In contrast, in rats with intra-ACC infusion of the D2 receptor antagonist eticlopride, the preference for the high-cost -high-reward response option was not altered relative to vehicle-treated rats. These data provide the first evidence that D1 receptors in the ACC regulate effort-based decision making.