Contraindications to progestin-only oral contraceptive pills among reproductive-aged women.
Contraindications to progestin-only oral contraceptive pills among reproductive-aged women.
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生殖时代妇女中仅孕激素避孕药的禁忌症。
DOI：
10.1016/j.contraception.2012.01.008
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发表时间：
2012-09
期刊：
影响因子：
2.9
通讯作者：
Grossman D
中科院分区：
文献类型：
--
作者：
White K;Potter JE;Hopkins K;Fernández L;Amastae J;Grossman D
与复方避孕药相比，单孕激素口服避孕药（POPs）的禁忌症较少。然而，尚未对育龄妇女中持久性有机污染物禁忌症的总体流行率进行评估。我们在两项研究中收集了持久性有机化合物禁忌症的信息：1)自我筛选研究，样本为德克萨斯州埃尔帕索市普通人群中的1,267名育龄妇女；2)口服避孕药（OC）使用者的前瞻性研究，样本为目前在埃尔帕索诊所（n=532）或墨西哥药店（n=514）获得避孕药的口服避孕药使用者。在自我筛选研究中，我们还比较了妇女使用检查表对禁忌症的自我评估和临床医生的评估。在自我筛查研究中，只有1.6%的妇女被确定为至少有一种持久性有机污染物禁忌症。该检查表识别至少有一种禁忌症的女性的敏感性为75.0% (95% CI: 50.6-90.4%)，特异性为99.4% （95% CI: 98.8-99.7%）。总体而言，在口服避孕药使用者的前瞻性研究中，0.6%的妇女报告有持久性有机污染物的禁忌症。临床和OTC使用者之间无显著差异。在这些样本中，持久性有机污染物禁忌症的流行率非常低。持久性有机污染物可能是美国第一种OTC口服避孕药的最佳选择。
Progestin-only oral contraceptive pills (POPs) have fewer contraindications to use compared to combined pills. However, the overall prevalence of contraindications to POPs among reproductive aged women has not been assessed. We collected information on contraindications to POPs in two studies: 1) the Self-Screening Study, a sample of 1,267 reproductive aged women in the general population in El Paso, Texas, and 2) the Prospective Study of Oral Contraceptive (OC) Users, a sample of current OC users who obtained their pills in El Paso clinics (n=532) or over the counter (OTC) in Mexican pharmacies (n=514). In the Self-Screening Study, we also compared women’s self-assessment of contraindications using a checklist to a clinician’s evaluation. Only 1.6% of women in the Self-Screening Study were identified as having at least one contraindication to POPs. The sensitivity of the checklist for identifying women with at least one contraindication was 75.0% (95% CI: 50.6–90.4%), and the specificity was 99.4% (95% CI: 98.8–99.7%). In total, 0.6% of women in the Prospective Study of OC Users reported having any contraindication to POPs. There were no significant differences between clinic and OTC users. The prevalence of contraindications to POPs was very low in these samples. POPs may be the best choice for the first OTC oral contraceptive in the US.
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影响因子：
4.1
作者：
McIntosh, Jennifer;Rafie, Sally;Besinque, Kathy
通讯作者：
Besinque, Kathy
影响因子：
7.2
作者：
Grossman, Daniel;Fernandez, Leticia;Potter, Joseph E.
通讯作者：
Potter, Joseph E.
影响因子：
7.2
作者：
Grossman, Daniel;White, Kari;Potter, Joseph E.
通讯作者：
Potter, Joseph E.
影响因子：
2.9
作者：
Shotorbani, S;Miller, L;Gardner, J
通讯作者：
Gardner, J
影响因子：
12.7
作者：
TRUSSELL, J;STEWART, F;ELLERTSON, C
通讯作者：
ELLERTSON, C