Effects of phenytoin on pyramidal neurons of the rat hippocampus.
Effects of phenytoin on pyramidal neurons of the rat hippocampus.
复制标题
苯妥英对大鼠海马锥体神经元的影响。
DOI：
10.1016/0006-8993(81)90582-5
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
Ayala,GF
中科院分区：
文献类型：
--
作者：
Hershkowitz,N;Ayala,GF
本文观察了苯妥英钠（35 μg/ml）对离体大鼠海马CA 1和CA 3区锥体神经元膜特性和抑制性突触后电位（IPSPs）的影响。输入电阻和静息膜电位无明显变化。动作电位幅值、超调、上升速率和衰减速率均降低。IPSP电导增加和逆转电位，诱发CA 3细胞通过苔藓纤维刺激和CA 1细胞通过经常性和Schaffer的侧支刺激，不受影响。
The effectsof phenytoin (35 μg/ml) on membrane properties and inhibitory postsynaptic potentials (IPSPs) in CA1 and CA3 pyramidal neurons of the in vitro rat hippocampus were examined. No significant change was observed on input resistance or resting membrane potential. Action potential amplitude, overshoot, rate of rise and rate of decay were decreased. IPSP conductance increase and reversal potential, evoked in CA3 cells through mossy fiber stimulation and in CA1 cells through recurrent and Schaffer's collateral stimulation, were unaffected.