Autologous mixed lymphocyte reaction in man. XIII. Characterization of the T-T autologous mixed lymphocyte reaction.
Autologous mixed lymphocyte reaction in man. XIII. Characterization of the T-T autologous mixed lymphocyte reaction.
复制标题
人类自体混合淋巴细胞反应。
DOI：
10.1007/bf00915510
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发表时间：
1985
影响因子：
9.1
通讯作者：
Goldberg,M
中科院分区：
文献类型：
--
作者：
Gupta,S;Chandy,G;Thornton,M;Goldberg,M
In this study we have demonstrated that in the T-TA autologous mixed lymphocyte reaction (AMLR), OKT4+T cells are the major responders; however, in the presence of additional interleukin-2 (IL-2), OKT8+T cells also respond by proliferation. Both OKT4+and OKT8+T cells, activated in the T-non-T AMLR, act as stimulators in the T-TA AMLR. OKT4+T cells activated in the T-TA AMLR suppress the proliferative response of the fresh T-non-T AMLR; control OKT4+cells show no immunoregulatory activity in this system. In contrast, control OKT8+T cells spontaneously suppress the proliferation of the T-non-T AMLR, but activation of OKT8+T cells in the T-TA AMLR does not result in a further increase in the suppressor activity of OKT8+T cells. In summary, in the T-non-T and T-TA AMLR phenotypically similar T-cell subpopulations proliferate but express distinct immunoregulatory functions and perhaps regulate the tempo of the AMLR.
