The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis.
The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis.
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DOI：
10.1007/s11481-015-9604-2
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Dash C
中科院分区：
文献类型：
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作者：
Passaro RC;Pandhare J;Qian HZ;Dash C
全球艾滋病毒/艾滋病大流行病夺去了估计3 500万人的生命。防治这一全球流行病的一个重大障碍是药物使用，因为它与艾滋病毒传播、诊断/治疗开始延迟和治疗依从性差有关。临床研究还表明，药物使用与艾滋病毒疾病进展/艾滋病相关死亡率之间存在联系。甲基苯丙胺（METH）的使用是世界上增长最快的物质使用问题之一。甲基苯丙胺的使用增加了高危性行为，因此增加了感染HIV-1的可能性。甲基苯丙胺的使用还与较高的病毒载量、免疫功能障碍和抗逆转录病毒耐药性有关。此外，甲基苯丙胺的使用也与艾滋病的快速发展有关。然而，甲基对HIV-1疾病进展的直接影响仍然知之甚少，因为甲基和其他非法药物的使用往往与减少/不遵守ART。然而，体外研究表明，甲基增加HIV-1复制细胞培养和动物模型。因此，有人提出，METH对HIV-1复制的增强作用可能部分导致HIV-1发病机制的恶化。然而，我们最近的数据表明，METH抑制HIV-1在CD 4 + T细胞中的复制，并挑战了这种模式。因此，本综述的目的是系统地检查已发表的文献，以更好地了解METH滥用和HIV-1疾病进展之间复杂的相互作用。
The global HIV/AIDS pandemic has claimed the lives of an estimated 35 million people. A significant barrier for combating this global pandemic is substance use since it is associated with HIV transmission, delayed diagnosis/initiation of therapy, and poor adherence to therapy. Clinical studies also suggest a link between substance use and HIV-disease progression/AIDS-associated mortality. Methamphetamine (METH) use is one of the fastest-growing substance use problems in the world. METH use enhances high-risk sexual behaviors, therefore increases the likelihood of HIV-1 acquisition. METH use is also associated with higher viral loads, immune dysfunction, and antiretroviral resistance. Moreover, METH use has also been correlated with rapid progression to AIDS. However, direct effects of METH on HIV-1 disease progression remains poorly understood because use of METH and other illicit drugs is often associated with reduced/non adherence to ART. Nevertheless, in vitro studies demonstrate that METH increases HIV-1 replication in cell cultures and animal models. Thus, it has been proposed that METH’s potentiating effects on HIV-1 replication may in part contribute to the worsening of HIV-1 pathogenesis. However, our recent data demonstrate that METH inhibits HIV-1 replication in CD4+ T cells and challenges this paradigm. Thus, the goal of this review is to systematically examine the published literature to better understand the complex interaction between METH abuse and HIV-1 disease progression.