Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats
Time-dependent effect of low-frequency stimulation on amygdaloid-kindling seizures in rats
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DOI：
10.1016/j.nbd.2008.03.007
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发表时间：
2008-07
影响因子：
6.1
通讯作者：
Deng-chang Wu;Zhenghao Xu;Shuang Wang;Qi Fang;Danqing Hu;Qing Li;Hong-Liu Sun;Shihong Zhang
中科院分区：
文献类型：
--
作者：
Deng-chang Wu;Zhenghao Xu;Shuang Wang;Qi Fang;Danqing Hu;Qing Li;Hong-Liu Sun;Shihong Zhang
低频电刺激（LFS）已被认为是治疗难治性癫痫的一种新选择。本研究旨在探讨癫痫发作后不同时间点给予点燃灶LFS是否对点燃发作有不同的作用。我们的研究结果表明：（i）在点燃动物中，在点燃刺激停止后立即给予LFS抑制点燃获得期间的癫痫发作阶段，而在后放电停止后给予LFS加速点燃进展至阶段1和阶段2。(ii)在完全点燃的动物中，当使用全身性发作阈值电流作为点燃刺激时，即刻LFS降低全身性发作的发生率和平均发作阶段，并缩短累积全身性发作持续时间（GSD）。然而，延迟LFS延长累积GSD和后放电持续时间。我们的研究表明LFS治疗有时间依赖性，立即LFS具有抗癫痫作用。
Low-frequency stimulation (LFS) has been considered as a new option for the treatment of intractable epilepsy. The present study was designed to determine whether LFS of the kindling focus given at different time points after seizures exert different roles on kindling seizures. Our results showed that: (i) In kindling animals, LFS delivered immediately after cessation of the kindling stimulus inhibited the seizure stage during kindling acquisition, whereas LFS delivered after the cessation of afterdischarge accelerated the kindling progression to stages 1 and 2. (ii) In fully kindled animals, when using the generalized seizure threshold current as the kindling stimulus, immediate LFS decreased the incidence of generalized seizures and the average seizure stage as well as shortened the cumulative generalized seizure duration (GSD). However, delayed LFS prolonged the cumulative GSD and afterdischarge duration. Our study indicates that there is a time-dependent aspect of LFS treatment, and immediate LFS has anti-epileptogenic action.