Convenient catalytic, enantioselective conjugate reduction of nitroalkenes using CuF2
Convenient catalytic, enantioselective conjugate reduction of nitroalkenes using CuF2
复制标题
DOI：
10.1021/ol048035h
复制
发表时间：
2004-11-25
期刊：
影响因子：
5.2
通讯作者：
Carreira, EM
中科院分区：
文献类型：
--
作者：
Czekelius, C;Carreira, EM
[图片]我们记录了一种新的催化剂系统的使用，用于硝基烯烃的对映选择性共轭还原，利用市售的CuF2和双膦JOSIPHOS作为配体。这种新方案不仅方便了各种光学活性硝基烷烃的制备，而且还为铜催化反应提供了新的见解。
[GRAPHICS]We document the use of a new catalyst system for the enantioselective conjugate reduction of nitroalkenes utilizing commercially available CuF2 and the bis-phosphine JOSIPHOS as a ligand. This new protocol not only facilitates ready access to a variety of optically active nitroalkanes, but the results provide also new insight into copper-catalyzed reactions.