Three-dimensional printed optical phantoms with customized absorption and scattering properties
Three-dimensional printed optical phantoms with customized absorption and scattering properties
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DOI：
10.1364/boe.6.004212
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发表时间：
2015-11-01
影响因子：
3.4
通讯作者：
Roblyer, Darren
中科院分区：
文献类型：
--
作者：
Diep, Phuong;Pannem, Sanjana;Roblyer, Darren
三维（3D）打印提供了制造具有任意几何形状的光学幻影的前景，但是市售的热塑性塑料仅提供小范围的生理相关吸收（mu（α））和降低的散射（mu（ε ′））值。在这里，我们展示了可定制的丙烯腈-丁二烯-苯乙烯（ABS）长丝，用于组织模仿光学模型的双挤出3D打印。通过在长丝挤出工艺中掺入苯胺黑和二氧化钛（TiO 2）来调节μ（α）和μ（s）′值。一个广泛的生理相关的光学性能被证明与平均重复性在11.5%的mu（a）和7.71%的mu（s）。此外，使用双挤出方法打印了一个模拟小鼠体模，该体模模拟了植入异种移植肿瘤的无毛小鼠的几何形状和光学特性。3D打印的肿瘤光学特性与活体肿瘤相匹配，在659 nm波长下误差小于3%。具有用户定义的光学特性的3D打印可以提供用于仪器表征和校准的持久光学漫射幻影的可行方法。(C)2015美国光学学会
Three-dimensional (3D) printing offers the promise of fabricating optical phantoms with arbitrary geometry, but commercially available thermoplastics provide only a small range of physiologically relevant absorption (mu(a)) and reduced scattering (mu(s)') values. Here we demonstrate customizable acrylonitrile butadiene styrene (ABS) filaments for dual extrusion 3D printing of tissue mimicking optical phantoms. mu(a) and mu(s)' values were adjusted by incorporating nigrosin and titanium dioxide (TiO2) in the filament extrusion process. A wide range of physiologically relevant optical properties was demonstrated with an average repeatability within 11.5% for mu(a) and 7.71% for mu(s)'. Additionally, a mouse-simulating phantom, which mimicked both the geometry and optical properties of a hairless mouse with an implanted xenograft tumor, was printed using dual extrusion methods. 3D printed tumor optical properties matched the live tumor with less than 3% error at a wavelength of 659 nm. 3D printing with user defined optical properties may provide a viable method for durable optically diffusive phantoms for instrument characterization and calibration. (C) 2015 Optical Society of America