Effects of arsenic(V) chromium(III) interaction on plasma glucose and cholesterol levels in growing rats
Effects of arsenic(V) chromium(III) interaction on plasma glucose and cholesterol levels in growing rats
复制标题
DOI：
10.1159/000177995
复制
发表时间：
1997-05-01
影响因子：
3.9
通讯作者：
Gonzalez, MJ
中科院分区：
文献类型：
--
作者：
Aguilar, MV;MartinezPara, MC;Gonzalez, MJ
最近的研究表明砷 (As) 和铬 (Cr) 之间的相互作用会影响吸收和/或蛋白质分解代谢。在本研究中，在断奶的雄性 Wistar 大鼠中检查了 As(V)/Cr(III) 相互作用对生长速率、器官重量和 Cr 的两个主要有机功能（即调节血浆葡萄糖水平和总血浆胆固醇水平）的可能影响。 20只大鼠的饮食中每克食物添加5μg As(V)和/或Cr(III)，持续10周。 As/Cr 相互作用并没有显着影响生长速率或器官重量：体重比，但确实降低了血浆总胆固醇水平，尽管降低幅度不像单独补充 Cr 的组那么明显 (p < 0.1)。由于补充 As(V) 会产生相反的效果（96.83 vs. 47.27）（p < 0.01），因此联合使用 As 和 Cr 可能对慢性 As(V) 中毒病例有益。 As(V) 和 Cr(III) 联合补充治疗对血糖水平没有显着影响，因为尽管 As(V) 影响 Cr 组织水平，从而改变 Cr 对血浆胆固醇水平的影响，但 As(V) 和 Cr(III) 各自的影响相似，因此基础血糖水平不受影响。
Recent studies have demonstrated interaction between arsenic (As) and chromium (Cr) affecting absorption and/or protein catabolism. In the present study the possible effects of As(V)/Cr(III) interaction on growth rate, organ weight, and the two main organic functions of Cr, i.e., regulation of plasma glucose levels and total plasma cholesterol levels, was examined in weaned male Wistar rats. The diet of 20 rats was supplemented with 5 mu g of As(V) and/or Cr(III) per gram of food for 10 weeks. As/Cr interaction did not significantly affect growth rates or organ weight:body weight ratios but did decrease total plasma cholesterol levels, though the decrease was not as pronounced as in the group supplemented with Cr alone (p < 0.1). Since supplementation with As(V) produced the opposite effect (96.83 vs. 47.27) (p < 0.01), the combined use of As and Cr may prove beneficial in cases of chronic As(V) intoxication. Supplementation treatment with As(V) and Cr(III) combined had no significant effect on glucose levels, because though As(V) affects Cr tissue levels and thus alters the effect of Cr on plasma cholesterol levels, individual effects of As(V) and Cr(III) are similar, and hence basal glucose levels are unaffected.