Independent circadian and sleep/wake regulation of adipokines and glucose in humans
Independent circadian and sleep/wake regulation of adipokines and glucose in humans
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DOI：
10.1210/jc.2004-2232
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发表时间：
2005-05-01
影响因子：
5.8
通讯作者：
Mantzoros, CS
中科院分区：
文献类型：
--
作者：
Shea, SA;Hilton, MF;Mantzoros, CS
瘦素和脂联素在调节食欲、食物摄入和能量平衡中发挥重要的生理作用，并且在肥胖和神经性厌食症中具有病理生理作用。为了评估行为（睡眠/觉醒周期和食物摄入）的昼夜模式以及内源性昼夜节律起搏器对观察到的脂肪因子昼夜模式的相对贡献，我们在六名健康受试者中测量了整个恒定常规方案（在恒定姿势、温度和昏暗光线下保持清醒38小时，以及每2小时相同的零食）以及整个睡眠和禁食期间循环瘦素、可溶性瘦素受体、脂联素、葡萄糖和胰岛素水平持续例行公事之前和之后的时期。瘦素、葡萄糖和胰岛素存在显着的内源性昼夜节律，在通常的觉醒时间附近达到峰值。睡眠/禁食导致瘦素、葡萄糖和胰岛素的额外系统性降低，而清醒/食物摄入则导致瘦素系统性增加。因此，瘦素的昼/夜模式可能是由内源性昼夜节律起搏器和行为的昼/夜模式的综合作用引起的。我们的数据表明，睡眠/觉醒时间表的改变将导致循环瘦素的每日范围增加，醒来时瘦素最低，这通过影响食物摄入和能量平衡，可能与轮班工作人群肥胖患病率的增加有关。
Leptin and adiponectin play important physiological roles in regulating appetite, food intake, and energy balance and have pathophysiological roles in obesity and anorexia nervosa. To assess the relative contributions of day/night patterns in behaviors (sleep/wake cycle and food intake) and of the endogenous circadian pacemaker on observed day/night patterns of adipokines, in six healthy subjects we measured circulating leptin, soluble leptin receptor, adiponectin, glucose, and insulin levels throughout a constant routine protocol ( 38 h of wakefulness with constant posture, temperature, and dim light, as well as identical snacks every 2 h) and throughout sleep and fasting periods before and after the constant routine. There were significant endogenous circadian rhythms in leptin, glucose, and insulin, with peaks around the usual time of awakening. Sleep/fasting resulted in additional systematic decreases in leptin, glucose, and insulin, whereas wakefulness/ food intake resulted in a systematic increase in leptin. Thus, the day/night pattern in leptin is likely caused by combined effects from the endogenous circadian pacemaker and day/night patterns in behaviors. Our data imply that alterations in the sleep/wake schedule would lead to an increased daily range in circulating leptin, with lowest leptin upon awakening, which, by influencing food intake and energy balance, could be implicated in the increased prevalence of obesity in the shift work population.