High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis
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DOI：
10.3899/jrheum.101261
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发表时间：
2011-06-01
影响因子：
3.9
通讯作者：
Dieude, Philippe
中科院分区：
文献类型：
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作者：
Aubart, Fleur;Crestani, Bruno;Dieude, Philippe
客观的。探讨类风湿性关节炎（RA）患者的抗环瓜氨酸肽抗体（抗CCP2）水平是否与肺部疾病的并发相关。方法。横断面研究共纳入 252 名 RA 患者。通过高分辨率胸部计算机断层扫描证实肺部疾病。使用 ELISA 对循环抗 CCP2 进行定量。进行多变量逻辑回归以确定肺部疾病的独立危险因素。结果。男性（OR 3.29，95% CI 1.59-6.80）和高抗CCP2水平（OR 1.49，95% CI 1.25-1.78）被确定为RA人群肺部疾病的独立危险因素。结论。高抗 CCP2 水平与 RA 人群中的肺部疾病相关。 （首次发布，2011 年 3 月 1 日；J Rheumatol 2011；38:979-82；doi:10.3899/jrheum.101261）
Objective. To investigate whether levels of anti-cyclic citrullinated peptide antibodies (anti-CCP2) in patients with rheumatoid arthritis (RA) are associated with the co-occurrence of lung diseases.Methods. A total of 252 RA patients were included in a cross-sectional study. Pulmonary disease was confirmed by high-resolution chest computed tomography scan. Circulating anti-CCP2 were quantified using ELISA. Multivariate logistic regression was conducted to identify independent risk factors for lung disease.Results. Male sex (OR 3.29, 95% CI 1.59-6.80) and high anti-CCP2 levels (OR 1.49, 95% CI 1.25-1.78) were identified as independent risk factors for lung disease in the RA population.Conclusion. High anti-CCP2 levels are associated with lung disease in the RA population. (First Release March 1 2011; J Rheumatol 2011;38:979-82; doi:10.3899/jrheum.101261)