Hemispheric asymmetry in human lateral prefrontal cortex during cognitive set shifting
Hemispheric asymmetry in human lateral prefrontal cortex during cognitive set shifting
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DOI：
10.1073/pnas.122644899
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发表时间：
2002-05-28
影响因子：
11.1
通讯作者：
Miyashita, Y
中科院分区：
文献类型：
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作者：
Konishi, S;Hayashi, T;Miyashita, Y
人类大脑半球的功能组织是不对称的专门化的，最典型的是沿着语言/非语言轴。在这项与事件相关的功能磁共振研究中，我们报告了另一个不对称特化的例子。研究人员使用了威斯康星州卡片分类测试中的集合转换范式，受试者根据环境反馈将一种行为更新为另一种行为。根据任务事件的时间阶段，将构成范式的认知要求分解为两个部分。在额叶外侧皮质的三对两侧区域中，发现了成分脑活动的双重分离，右侧区域在接受负反馈时被激活，相应的左侧区域在行为更新时被激活，这表明两个半球都对认知集转移做出了贡献，但方式不同。同一范式内的不对称半球专业化进一步意味着实现共同目标的这些任务组成部分的半球间相互作用。
Functional organization of human cerebral hemispheres is asymmetrically specialized, most typically along a verbal/nonverbal axis. In this event-related functional MRI study, we report another example of the asymmetrical specialization. Set-shifting paradigms derived from the Wisconsin card sorting test were used, where subjects update one behavior to another on the basis of environmental feedback. The cognitive requirements constituting the paradigms were decomposed into two components according to temporal stages of task events. Double dissociation of the component brain activity was found in the three bilateral pairs of regions in the lateral frontal cortex, the right regions being activated during exposure to negative feedback and the corresponding left regions being activated during updating of behavior, to suggest that both hemispheres contribute to cognitive set shifting but in different ways. The asymmetrical hemispheric specialization within the same paradigms further implies an interhemispheric interaction of these task components that achieve a common goal.