From worms to humans: Understanding intestinal lipid metabolism via model organisms
From worms to humans: Understanding intestinal lipid metabolism via model organisms
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DOI：
10.1016/j.bbalip.2023.159290
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发表时间：
2023-02-10
影响因子：
4.8
通讯作者：
Farber, Steven A.
中科院分区：
文献类型：
--
作者：
Kozan, Darby W.;Derrick, Joshua T.;Farber, Steven A.
在膳食脂质进入循环系统之前，肠道负责有效地吸收和包装它们。本文综述了来自不同模式生物的肠细胞如何吸收膳食脂质并随后分泌最大种类的脂蛋白（乳糜微粒）以满足每种动物的独特需求。我们讨论了饮食与代谢性疾病进展，特别是2型糖尿病之间的推定关系。了解肠道细胞对膳食脂质的分子反应有可能发现对抗代谢综合征的新疗法。
The intestine is responsible for efficient absorption and packaging of dietary lipids before they enter the circu-latory system. This review provides a comprehensive overview of how intestinal enterocytes from diverse model organisms absorb dietary lipid and subsequently secrete the largest class of lipoproteins (chylomicrons) to meet the unique needs of each animal. We discuss the putative relationship between diet and metabolic disease progression, specifically Type 2 Diabetes Mellitus. Understanding the molecular response of intestinal cells to dietary lipid has the potential to undercover novel therapies to combat metabolic syndrome.