Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
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DOI：
10.1002/ana.20009
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发表时间：
2004-03-01
影响因子：
11.2
通讯作者：
Långström, B
中科院分区：
文献类型：
--
作者：
Klunk, WE;Engler, H;Långström, B
本报告描述了对一种新型淀粉样蛋白成像正电子发射断层扫描（PET）示踪剂（称为匹兹堡化合物 - B（PIB））进行的首次人体研究，研究对象为16名已确诊为轻度阿尔茨海默病（AD）的患者和9名对照者。与对照者相比，AD患者通常在已知AD中含有大量淀粉样蛋白沉积的联合皮质区域显示出PIB的显著滞留。在AD患者组中，额叶皮质的PIB滞留增加最为显著（1.94倍，p = 0.0001）。在顶叶（1.71倍，p = 0.0002）、颞叶（1.52倍，p = 0.002）和枕叶（1.54倍，p = 0.002）皮质以及纹状体（1.76倍，p = 0.0001）也观察到大幅增加。在已知相对不受淀粉样蛋白沉积影响的区域（如下皮质白质、脑桥和小脑），AD患者和对照者的PIB滞留相当。对3名年轻（21岁）和6名年长健康对照者（69.5 ± 11岁）的研究显示，皮质区域的PIB滞留较低，年轻和年长对照者之间无显著组间差异。在皮质区域，PIB滞留与用18F - 氟脱氧葡萄糖测定的脑葡萄糖代谢呈负相关。这种关系在顶叶皮质最为显著（r = -0.72；p = 0.0001）。结果表明，使用新型示踪剂PIB进行的PET成像能够提供活体受试者中淀粉样蛋白沉积的定量信息。
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.