Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries
Development and feasibility study of a two-dimensional ultrasonic-measurement-integrated blood flow analysis system for hemodynamics in carotid arteries
复制标题
颈动脉血流动力学二维超声测量一体化血流分析系统的研制及可行性研究
DOI：
10.1007/s11517-014-1193-3
复制
发表时间：
2014
影响因子：
3.2
通讯作者：
Lei Liu
中科院分区：
文献类型：
--
作者：
Takaumi Kato;Kenichi Funamoto;Toshiyuki Hayase;Shusaku Sone;Hiroko Kadowaki;Tadashi Shimazaki;Takao Jibiki;Koji Miyama;Lei Liu
预防和早期发现动脉粥样硬化对于预防随后的循环系统疾病至关重要。在这项研究中，开发了一种用于临床诊断的自动化二维超声测量集成（2D-UMI）血流分析系统，并揭示了该系统用于颈动脉血流动力学分析的可行性。系统根据超声彩色多普勒成像自动生成二维计算域，并对血流场进行UMI模拟，以可视化该域内的血流动力学。在UMI模拟中，通过测量和计算添加与多普勒速度之间的差异成比例的反馈信号来进行误差补偿，同时自动估计横截面平均流入速度。通过分析五根颈动脉（三根健康、一根硬化、一根狭窄）的血流来检查反馈增益调整的必要性。根据目标变量，相同的反馈增益通常适用于所有颈动脉的 2D-UMI 模拟。因此，本系统在参数与患者无关的意义上被证明是通用的。此外，还提出了一种基于 2D-UMI 模拟获得的血流动力学信息（例如横截面平均流入速度波形和壁剪切应力分布）的新诊断方法的可能性。
Prevention and early detection of atherosclerosis are critical for protection against subsequent circulatory disease. In this study, an automated two-dimensional ultrasonic-measurement-integrated (2D-UMI) blood flow analysis system for clinical diagnosis was developed, and the feasibility of the system for hemodynamic analysis in a carotid artery was revealed. The system automatically generated a 2D computational domain based on ultrasound color Doppler imaging and performed a UMI simulation of blood flow field to visualize hemodynamics in the domain. In the UMI simulation, compensation of errors was applied by adding feedback signals proportional to the differences between Doppler velocities by measurement and computation while automatically estimating the cross-sectional average inflow velocity. The necessity of adjustment of the feedback gain was examined by analyzing blood flow in five carotid arteries: three healthy, one sclerosed, and one stenosed. The same feedback gain was generally applicable for the 2D-UMI simulation in all carotid arteries, depending on target variables. Thus, the present system was shown to be versatile in the sense that the parameter is patient independent. Moreover, the possibility of a new diagnostic method based on the hemodynamic information obtained by the 2D-UMI simulation, such as a waveform of the cross-sectional average inflow velocity and wall shear stress distributions, was suggested.