Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis.
Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis.
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DOI：
10.1111/cas.12202
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发表时间：
2013-09
期刊：
影响因子：
5.7
通讯作者：
Guo F
中科院分区：
文献类型：
--
作者：
Lin Y;Wei C;Liu Y;Qiu Y;Liu C;Guo F
Tumor-associated macrophages (TAMs) play a critical role in promoting tumor development and metastasis. In this study, we found that legumain, an asparaginyl endopeptidase, was highly expressed on the surface of TAMs. A doxorubicin-based prodrug specifically activated by legumain selectively ablated TAMs and resulted in a significant reduction of angiogenic factors and related tumor vessel growth. Treatment with the prodrug also suppressed circulating tumor cells and myeloid immune suppressor Gr-1+ /CD11b+ cells in tumor-bearing animals. After selective ablation of TAMs by the prodrug, the tumor growth and metastases were greatly inhibited in murine tumor models. These results indicate that legumain-activated prodrugs targeting TAMs in tumors may represent a novel anti-cancer strategy.
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影响因子：
158.5
作者：
Cristofanilli, M;Budd, GT;Hayes, DF
通讯作者：
Hayes, DF
DOI：
10.1073/pnas.93.25.14833
发表时间：
1996-12-10
影响因子：
11.1
作者：
Ramprasad, MP;Terpstra, V;Steinberg, D
通讯作者：
Steinberg, D
影响因子：
15.9
作者：
Patel, Naina;Krishnan, Shekhar;Saha, Vaskar
通讯作者：
Saha, Vaskar
影响因子：
3.5
作者：
Chen, JM;Rawlings, ND;Barrett, AJ
通讯作者：
Barrett, AJ
影响因子：
15.9
作者：
Luo, Yunping;Zhou, He;Xiang, Rong
通讯作者：
Xiang, Rong