Animal models for screening anxiolytic-like drugs: a perspective
Animal models for screening anxiolytic-like drugs: a perspective
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筛选抗焦虑类药物的动物模型：一个视角
DOI：
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发表时间：
2015
影响因子：
8.3
通讯作者：
M. Bourin
中科院分区：
文献类型：
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作者：
M. Bourin
当代生物精神病学使用实验动物模型来增加我们对情感障碍发病机制的了解。现代抗焦虑药物的发现主要针对单一表型域中的特定途径和分子决定簇。然而，通过动物模型可以更好地了解作用机制。最初是用大鼠开发的，焦虑的动物模型已经被用于小鼠，这是一种易于使用的哺乳动物，具有比大鼠更好的遗传可能性。在这篇综述中，我们重点介绍了三种最常见的小鼠焦虑动物模型用于抗焦虑药物的筛选。描述了条件和非条件模型，以代表所有类型的焦虑动物模型。行为研究需要仔细注意与环境，处理，或范式变量参数，这也进行了讨论。最后，我们集中在重新暴露于设备的后果。重测程序可以提供新的答案，但应该深入研究，以重新验证整个范式作为一个动物模型的焦虑。
Contemporary biological psychiatry uses experimental animal models to increase our understanding of affective disorder pathogenesis. Modern anxiolytic drug discovery mainly targets specific pathways and molecular determinants within a single phenotypic domain. However, greater understanding of the mechanisms of action is possible through animal models. Primarily developed with rats, animal models in anxiety have been adapted with mixed success for mice, easy-to-use mammals with better genetic possibilities than rats. In this review, we focus on the three most common animal models of anxiety in mice used in the screening of anxiolytics. Both conditioned and unconditioned models are described, in order to represent all types of animal models of anxiety. Behavioral studies require careful attention to variable parameters linked to environment, handling, or paradigms; this is also discussed. Finally, we focus on the consequences of re-exposure to the apparatus. Test-retest procedures can provide new answers, but should be intensively studied in order to revalidate the entire paradigm as an animal model of anxiety.